Cdc14 plans autophagy for meiotic cell divisions
Wenzhi Feng1, Orlando Argüello-Miranda2, Suhong Qian1
1Department of Cell Biology, UT Southwestern Medical Center, Dallas, TX, USA.
Autophagy
|May 26, 2022
Summary
Autophagy oscillates during meiosis, accelerating cell division and improving sporulation. The phosphatase Cdc14 triggers this process by dephosphorylating Atg13, coordinating autophagy with meiotic progression.
Area of Science:
- Cell Biology
- Molecular Biology
- Genetics
Background:
- Proteasome-mediated degradation is a well-studied meiotic process.
- Macroautophagy/autophagy is a newly recognized regulator of meiosis progression.
Purpose of the Study:
- To investigate the temporal pattern and regulation of autophagy during meiosis.
- To elucidate the role of Cdc14 in controlling autophagy during meiotic divisions.
Main Methods:
- In vitro and in vivo assays were employed.
- Analysis of autophagic activity patterns in meiotic cells.
- Investigation of Cdc14 localization and interactions during meiosis.
Main Results:
- Autophagy exhibits a distinct temporal pattern in meiotic cells, oscillating during meiosis I and II.
- Oscillating autophagic activity accelerates meiotic progression and enhances sporulation efficiency.
- The phosphatase Cdc14 stimulates autophagy initiation in anaphase I and II by dephosphorylating Atg13, activating Atg1 kinase.
Conclusions:
- Autophagy is dynamically regulated during meiosis, with oscillations contributing to efficient meiotic progression.
- Cdc14 plays a crucial role in coordinating autophagy with meiotic events through Atg13 regulation.
- This study reveals a novel mechanism linking autophagy to meiotic coordination.
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