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Synthesis of 2'-deoxy-6,3'-methano-cyclo-pyrimidine nucleosides
Nucleic Acids Symposium Series
|January 1, 1986
Abstract:
The nucleophilic attack of lithiated pyrimidines to a suitably-protected 3-ketosugar, afforded the 3-branched sugar stereospecifically, followed by intramolecular glycosylation to give 6,3'-methano-cyclo-pyrimidine nucleosides. The 2'-deoxygenation was achieved by sequential protection, deprotection and radical reduction.