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Probiotics Function in Preventing Atopic Dermatitis in Children.

Caterina Anania1, Giulia Brindisi1, Ivana Martinelli1

  • 1Department of Mother-Child, Urological Science, Sapienza University of Rome, 00161 Rome, Italy.

International Journal of Molecular Sciences
|May 28, 2022
PubMed
Summary

Probiotics may help prevent atopic dermatitis (AD) in children by modulating the gut microbiota. Further research is needed to clarify their efficacy and underlying anti-allergic mechanisms.

Keywords:
atopic dermatitischildrenpreventionprobiotics

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Area of Science:

  • Immunology
  • Dermatology
  • Microbiology

Background:

  • Atopic dermatitis (AD) is a chronic inflammatory skin condition with increasing prevalence.
  • The gut microbiota influences systemic immunity and allergic responses.
  • Probiotics are being explored for their potential role in AD prevention.

Purpose of the Study:

  • To review current evidence on probiotic supplementation for preventing atopic dermatitis in children.
  • To discuss potential biological mechanisms behind probiotic-mediated anti-allergic effects.

Main Methods:

  • Narrative review of existing clinical studies and scientific literature.
  • Examination of research on gut microbiota and immune system interactions.
  • Analysis of studies investigating probiotic efficacy in pediatric AD prevention.

Main Results:

  • Evidence suggests a potential role for probiotics in AD prevention, though mechanisms require further elucidation.
  • Controversy exists regarding the definitive efficacy of probiotics for AD prevention.
  • Gut microbiota modulation by probiotics may influence allergic sensitization.

Conclusions:

  • Probiotic supplementation shows promise for atopic dermatitis prevention in pediatric populations.
  • Further investigation into the molecular mechanisms of probiotic action is warranted.
  • Clarifying probiotic efficacy is crucial for clinical application in AD prevention.