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Resveratrol and Curcumin for Chagas Disease Treatment-A Systematic Review
Carlos Henrique Lima Imperador1, Cauê Benito Scarim2, Priscila Longhin Bosquesi1,2
1Advanced Research Center in Medicine (CEPAM), School of Medicine, Union of the Colleges of the Great Lakes (UNILAGO), Sao Jose do Rio Preto 15030-070, SP, Brazil.
Pharmaceuticals (Basel, Switzerland)
|May 28, 2022
Summary
Resveratrol and curcumin show promise for treating Chagas disease (CD) complications. While no clinical studies exist, animal research suggests these natural compounds may mitigate cardiac and digestive issues in chronic Chagas disease.
Area of Science:
- Parasitology
- Pharmacology
- Natural Products
Background:
- Chagas disease (CD), caused by *Trypanosoma cruzi*, affects millions globally, with limited treatment options for chronic manifestations like cardiomyopathy and digestive issues.
- Immuno-inflammatory pathways drive CD progression, highlighting the need for therapies with antioxidant and anti-inflammatory properties.
- Resveratrol (RVT) and curcumin (CUR) are natural compounds with demonstrated antioxidant and anti-inflammatory effects, suggesting potential therapeutic benefits for CD.
Purpose of the Study:
- To systematically review the effectiveness of Resveratrol (RVT) and curcumin (CUR) in treating Chagas disease (CD).
- To analyze existing animal and clinical research on RVT and CUR for CD treatment, adhering to PRISMA guidelines.
Main Methods:
- Systematic review conducted according to PRISMA guidelines and registered on PROSPERO.
- Analysis of eligible animal research reports using SYRCLES risk of bias tools and ARRIVE 2.0 guidelines.
- Exclusion of clinical studies due to a lack of available research.
Main Results:
- No clinical studies were identified for the treatment of Chagas disease with RVT or CUR.
- Nine eligible animal research reports were analyzed, indicating potential benefits of RVT and CUR.
- The review discusses potential derivatives of RVT and CUR for future CD treatment strategies.
Conclusions:
- Current evidence for Resveratrol and curcumin in Chagas disease treatment is limited to animal models.
- Further research, including clinical trials, is needed to validate the efficacy of RVT and CUR for Chagas disease.
- Exploring RVT and CUR derivatives may offer novel therapeutic avenues for managing Chagas disease complications.
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