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Solid Lipid Nanoparticles SLNs for Intracellular Targeting Applications
Published on: November 17, 2015
Functionalized lipid-based drug delivery nanosystems for the treatment of human infectious diseases
Bruna Almeida Furquim de Camargo1, Bruno Fonseca-Santos2, Suzana Gonçalves Carvalho1
1School of Pharmaceutical Sciences, São Paulo State University (UNESP), Araraquara, Brazil.
Abstract:
Infectious diseases are still public health problems. Microorganisms such as fungi, bacteria, viruses, and parasites are the main causing agents related to these diseases. In this context, the search for new effective strategies in prevention and/or treatment is considered essential, since current drugs often have side effects or end up, causing microbial resistance, making it a serious health problem. As an alternative to these limitations, nanotechnology has been widely used. The use of lipid-based drug delivery nanosystems (DDNs) has some advantages, such as biocompatibility, low toxicity, controlled release, the ability to carry both hydrophilic and lipophilic drugs, in addition to be easel scalable. Besides, as an improvement, studies involving the conjugation of signalling molecules on the surfaces of these nanocarriers can allow the target of certain tissues or cells. Thus, this review summarizes the performance of functionalized lipid-based DDNs for the treatment of infectious diseases caused by viruses, including SARS-CoV-2, bacteria, fungi, and parasites.
Insights
Functionalized lipid-based nanocarriers offer a promising alternative for treating infectious diseases. These systems show potential against viruses, bacteria, fungi, and parasites, overcoming limitations of current antimicrobial drugs.
Area of Science:
- Nanotechnology
- Infectious Diseases
- Drug Delivery Systems
Background:
- Infectious diseases caused by viruses, bacteria, fungi, and parasites remain significant global health challenges.
- Current treatments face limitations including side effects and the emergence of antimicrobial resistance.
- Nanotechnology presents an alternative approach to combat these issues.
Conclusions:
- Functionalized lipid-based DDNs represent a viable and advanced strategy for infectious disease management.
- Nanotechnology-based drug delivery systems offer significant advantages over conventional therapies.
- Further research into functionalized DDNs holds promise for developing novel treatments against a spectrum of pathogens.
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