Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Muscle Recovery and Fatigue01:24

Muscle Recovery and Fatigue

2.7K
Muscle fatigue refers to the decline in a muscle's ability to maintain the force of contraction after prolonged activity. It primarily stems from changes within muscle fibers. Even before experiencing muscle fatigue, one may feel tired and have the urge to stop the activity. This response, known as central fatigue, occurs due to changes in the central nervous system, namely the brain and spinal cord. While there is no single mechanism that induces fatigue, it may serve as a protective...
2.7K
Self-Regulation01:25

Self-Regulation

9
Self-regulation, also known as self-control, encompasses a range of cognitive and behavioral processes that allow individuals to adjust their internal states and outward actions to align with socially acceptable norms and long-term goals. It plays a fundamental role in adaptive functioning, from resisting impulsive behaviors to persisting through challenging tasks. While its benefits are widely recognized, self-regulation is not limitless. Muraven and Baumeister's theory posits that...
9
The Influence of Cognition on Affect01:29

The Influence of Cognition on Affect

2
Cognition plays a pivotal role in shaping emotional experiences, as demonstrated by Schachter and Singer’s two-factor theory of emotion. According to this model, emotion arises from a combination of physiological arousal and cognitive interpretation. The body’s physiological response to stimuli is ambiguous and only gains emotional significance through cognitive labeling. For instance, an increased heart rate and adrenaline surge while standing near an attractive person may be...
2
Fatigue01:21

Fatigue

254
Fatigue occurs when materials rupture under repeated or fluctuating loads, even at stress levels far below their static breaking strength. It typically results in brittle failure, even for ductile materials. It is a critical consideration in designing machines and structural components subjected to repetitive or varying loads. The nature of these loadings can range from fluctuating loads like unbalanced pump impellers causing vibrations to repeatedly bending a thin steel rod wire back and forth...
254
Cognitivism01:17

Cognitivism

1.7K
Cognitive psychology emerged as a significant field in the mid-20th century. It focused on understanding humans' internal mental processes. This approach emphasizes how people perceive, remember, think, and solve problems—elements critical to human cognition.
Previously dominated by behaviorism, which prioritized observable behaviors and largely ignored mental processes, psychology transformed in the 1950s. Cognitive psychologists argue that understanding how we think and process...
1.7K
Role of Cerebellum and Prefrontal Cortex in Memory01:14

Role of Cerebellum and Prefrontal Cortex in Memory

611
The cerebellum, while traditionally associated with motor control, also plays a crucial role in memory, particularly in procedural memory, which involves learning motor tasks that become automatic through repetition. For example, studies have shown that when the cerebellum is damaged, individuals or animals lose the ability to learn conditioned motor responses, such as the conditioned eye-blink response in classical conditioning experiments with rabbits. This study demonstrates the...
611

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Interactions of Patent Ductus Arteriosus and Ventilation on Preterm Pulmonary Vascular Disease.

Pediatric pulmonology·2025
Same author

Response to "The importance of considering variability in re-expression of effect estimates for use in meta-analysis." (Kopylev and Dzierlenga 2025).

BMC medical research methodology·2025
Same author

Estimating hypoxia-induced brain dysfunction and cognitive decline through exhaled breath monitoring.

Respiratory research·2025
Same author

Evaluation of a high-throughput in-vitro-to-in-vivo extrapolation (IVIVE) workflow for the prioritization of potential developmental toxicity of chemicals.

ALTEX·2025
Same author

Enabling transparent toxicokinetic modeling for public health risk assessment.

PloS one·2025
Same author

Evaluation of the validity of a perfluorooctane sulfonic acid exposure reconstruction using a measured serum concentration among workers with a wide range of exposure.

Annals of work exposures and health·2024

Related Experiment Video

Updated: Sep 21, 2025

The Effect of Anti-Fatigue Decoction on the Behaviors and Serological Indicators in a Central Fatigue Rat Model
05:38

The Effect of Anti-Fatigue Decoction on the Behaviors and Serological Indicators in a Central Fatigue Rat Model

Published on: April 12, 2024

386

Physiocognitive Modeling: Explaining the Effects of Caffeine on Fatigue.

Tim Halverson1, Christopher W Myers2, Jeffery M Gearhart3

  • 1Aptima Inc.

Topics in Cognitive Science
|May 31, 2022
PubMed
Summary

This study integrates physiological models with cognitive architecture to predict how caffeine affects fatigue. Findings explain caffeine's impact on performance metrics in sleep-deprived individuals.

Keywords:
ACT-RCaffeineComputational modelingFatiguePhysiologically based pharmacokinetic modeling

More Related Videos

A Rat Model of Central Fatigue Using a Modified Multiple Platform Method
05:13

A Rat Model of Central Fatigue Using a Modified Multiple Platform Method

Published on: August 14, 2018

9.2K
The Treadmill Fatigue Test: A Simple, High-throughput Assay of Fatigue-like Behavior for the Mouse
09:25

The Treadmill Fatigue Test: A Simple, High-throughput Assay of Fatigue-like Behavior for the Mouse

Published on: May 31, 2016

19.1K

Related Experiment Videos

Last Updated: Sep 21, 2025

The Effect of Anti-Fatigue Decoction on the Behaviors and Serological Indicators in a Central Fatigue Rat Model
05:38

The Effect of Anti-Fatigue Decoction on the Behaviors and Serological Indicators in a Central Fatigue Rat Model

Published on: April 12, 2024

386
A Rat Model of Central Fatigue Using a Modified Multiple Platform Method
05:13

A Rat Model of Central Fatigue Using a Modified Multiple Platform Method

Published on: August 14, 2018

9.2K
The Treadmill Fatigue Test: A Simple, High-throughput Assay of Fatigue-like Behavior for the Mouse
09:25

The Treadmill Fatigue Test: A Simple, High-throughput Assay of Fatigue-like Behavior for the Mouse

Published on: May 31, 2016

19.1K

Area of Science:

  • Cognitive Science
  • Computational Neuroscience
  • Pharmacology

Background:

  • Computational cognitive theories often omit physiological factors.
  • Understanding environmental compound effects on cognition is crucial for predicting behavioral changes.
  • Caffeine is a widely used stimulant with known cognitive effects.

Purpose of the Study:

  • To integrate physiologically based pharmacokinetic (PBPK) models with ACT-R's fatigue module.
  • To predict the cognitive effects of caffeine on fatigue by linking PBPK caffeine concentrations to ACT-R parameters.
  • To explain observed performance data in sleep-deprived individuals using this integrated model.

Main Methods:

  • Physiologically Based Pharmacokinetic (PBPK) modeling was used to predict caffeine concentrations in blood and tissues.
  • ACT-R's fatigue module was adapted by mapping PBPK parameters to ACT-R parameters, guided by neurophysiological literature.
  • Three parameter mappings were explored to analyze data from sleep-deprived participants on the Psychomotor Vigilance Test (PVT) with and without caffeine.

Main Results:

  • The integrated PBPK-ACT-R model successfully predicted caffeine's effects on fatigue.
  • Brain caffeine concentrations were used to modulate procedural parameters within the ACT-R fatigue module.
  • The model explained caffeine's influence on multiple performance metrics in sleep-deprived individuals during the PVT.

Conclusions:

  • Integrating physiological pharmacokinetic models with cognitive architectures provides a robust framework for understanding stimulant effects.
  • This approach enhances the predictive power of cognitive models by incorporating biological variability.
  • The study demonstrates a method for quantifying the impact of compounds like caffeine on cognitive performance and fatigue.