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MRI-based Texture Analysis of Infrapatellar Fat Pad to Predict Knee Osteoarthritis Incidence
1From the Clinical Research Centre, Zhujiang Hospital, Southern Medical University, Guangzhou, Guangdong, China (J.L., Z.Z., P.C., T.C., X.W., D.J.H., C.D.); Department of Orthopedics, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong, China (J.L.); School of Biomedical Engineering, Southern Medical University, Guangzhou, China (S.F., D.Z., J.M.); Department of Rehabilitation Medicine, Zhujiang Hospital, Southern Medical University, Guangzhou, China (Z.G.); School of Rehabilitation Medicine, Southern Medical University, Guangzhou, China (Z.G.); Department of Radiology, Zhujiang Hospital, Southern Medical University, Guangzhou, China (T.L.); Department of Orthopedics, The Third Affiliated Hospital of Southern Medical University, Guangzhou, China (T.C.); Department of Biomedical Engineering, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio (R.L.); University of Arizona College of Medicine, Tucson, Ariz (C.K.K.); University of Pittsburgh Graduate School of Public Health, Pittsburgh, Pa (C.K.K.); Department of Radiology, VA Boston Healthcare System, Boston University School of Medicine, Boston, Mass (A.G., F.W.R.); Department of Radiology, University of Erlangen-Nuremberg, Erlangen, Germany (F.W.R.); Department of Rheumatology, Royal North Shore Hospital and Sydney Musculoskeletal Health, Kolling Institute, University of Sydney, Australia (D.J.H.); and Menzies Institute for Medical Research, University of Tasmania, Hobart, Australia (C.D.).
Abstract:
Background Infrapatellar fat pad (IPFP) quality has been implicated as a marker for predicting knee osteoarthritis (KOA); however, no valid quantification for subtle IPFP abnormalities has been established. Purpose To investigate whether MRI-based three-dimensional texture analysis of IPFP abnormalities could help predict incident radiographic KOA. Materials and Methods In this prospective nested case-control study, 690 participants whose knees were at risk for KOA were included from the Pivotal Osteoarthritis Initiative MRI Analyses incident osteoarthritis cohort. All knees had a Kellgren-Lawrence grade of 1 or less at baseline. During the 4-year follow-up, case participants were matched 1:1 to control participants, with incident radiographic KOA as the outcome. MRI scans were segmented at the incident time point of KOA (hereafter, P0), 1 year before P0 (hereafter, P-1), and baseline. MRI-based three-dimensional texture analysis was performed to extract IPFP texture features. Least absolute shrinkage and selection operator and multivariable logistic regressions were applied in the development cohort and evaluated in the test cohort. The area under the receiver operating characteristic curve (AUC) was used to evaluate the discriminative value of the clinical score, IPFP texture score, and MRI Osteoarthritis Knee Score. Results Participants were allocated to development (n = 500, 340 women; mean age, 60 years) and test (n = 190, 120 women; mean age, 61 years) cohorts. In both cohorts, IPFP texture scores (AUC ≥0.75 for all) showed greater discrimination than clinical scores (AUC ≤0.69 for all) at baseline, P-1, and P0, with significant differences in pairwise comparisons (P ≤ .002 for all). Greater predictive and concurrent validities of IPFP texture scores (AUC ≥0.75 for all) compared with MRI Osteoarthritis Knee Scores (AUC ≤0.66 for all) were also demonstrated (P < .001 for all). Conclusion MRI-based three-dimensional texture of the infrapatellar fat pad was associated with future development of knee osteoarthritis. ClinicalTrials.gov registration no.: NCT00080171 © RSNA, 2022 Online supplemental material is available for this article. See also the editorial by Fischer in this issue.
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