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Related Concept Videos

Hypodermis01:02

Hypodermis

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The hypodermis (the subcutaneous layer or superficial fascia) is present directly below the dermis. It connects the skin to the underlying fascia (fibrous tissue) of the bones and muscles. It is not strictly a part of the skin, although the border between the hypodermis and dermis can be difficult to distinguish. The hypodermis consists of well-vascularized, loose, areolar connective tissue and adipose tissue, which functions as a mode of fat storage and provides insulation and cushioning for...
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Visualization and Quantification of Brown and Beige Adipose Tissues in Mice using [18F]FDG Micro-PET/MR Imaging
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Brown Adipose Tissue-A Translational Perspective.

André C Carpentier1, Denis P Blondin2, François Haman3

  • 1Division of Endocrinology, Department of Medicine, Centre de recherche du Centre hospitalier universitaire de Sherbrooke, Université de Sherbrooke, Sherbrooke, Quebec, J1H 5N4, Canada.

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Summary
This summary is machine-generated.

Brown adipose tissue (BAT) generates heat, offering a therapeutic target for metabolic diseases. However, selective activation and measurement of BAT

Keywords:
adipose tissuesbrown adipose tissuediabetesenergy metabolismglucose metabolisminsulin resistancelipid metabolismobesitythermogenesis

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Area of Science:

  • Brown adipose tissue (BAT) research.
  • Metabolic and endocrine system regulation.
  • Human thermoregulation and energy balance.

Background:

  • BAT's unique heat-generating capacity via uncoupled oxidative phosphorylation makes it a therapeutic target for cardiometabolic diseases.
  • Current human studies primarily measure BAT via 18F-fluorodeoxyglucose uptake, which may not reflect thermogenic activity, especially in insulin resistance.
  • BAT thermogenesis relies on intracellular fatty acids from triglyceride lipolysis, a process linked to other metabolic tissues.

Approach:

  • Review of cellular metabolism and regulation of brown adipose tissue.
  • Analysis of central nervous, endocrine, and metabolite influences on BAT.
  • Examination of current pharmacological stimulation strategies and measurement techniques for human BAT.

Key Points:

  • BAT's thermogenic potential for treating metabolic disorders.
  • Limitations in current methods for measuring human BAT activity and thermogenesis.
  • The need for selective BAT activation strategies and improved measurement tools.

Conclusions:

  • Brown adipose tissue is a promising target for metabolic diseases, but its selective activation remains challenging.
  • Existing measurement techniques for human BAT may not accurately reflect thermogenic function.
  • Further research requires improved methods to directly assess BAT thermogenic capacity and its role in cardiometabolic health.