Piezoelectric Activatable Nanozyme-Based Skin Patch for Rapid Wound Disinfection

Area of Science:

• Materials Science
• Nanotechnology
• Biomedical Engineering
• Antimicrobial Therapy

Background:

• Nanozymes offer advantages like low cost and high stability for antibacterial applications.
• Limited catalytic activity of conventional nanozymes restricts their efficacy against infections.
• Need for advanced nanozymes with enhanced antibacterial properties and reduced resistance is critical.

Purpose of the Study:

• To engineer a novel nanozyme with enhanced piezocatalytic and peroxidase-like activities.
• To investigate the antibacterial efficacy of the developed nanozyme against multidrug-resistant pathogens.
• To develop a practical application of the nanozyme for rapid skin wound disinfection.

Main Methods:

• Fabrication of zinc oxide nanorod@graphdiyne nanosheet (ZnO@GDY NR) heterostructures.
• Evaluation of piezocatalytic and peroxidase-like activities under ultrasound irradiation.
• Assessment of antibacterial efficacy against methicillin-resistant Staphylococcus aureus and Pseudomonas aeruginosa in vitro and in vivo.
• Development and testing of a piezoelectric activatable nanozyme-based skin patch for wound disinfection.

Main Results:

• The ZnO@GDY NR heterostructure exhibited significant piezocatalytic and peroxidase-like activities.
• Ultrasound irradiation promoted H2O2 decomposition and reactive oxygen species generation.
• Achieved nearly 100% antibacterial efficacy against tested multidrug-resistant pathogens.
• The developed skin patch demonstrated effective and rapid skin wound disinfection with good biocompatibility.

Conclusions:

• The engineered ZnO@GDY NR piezocatalytic nanozyme overcomes limitations of traditional nanozymes.
• This nanozyme shows potent antibacterial activity against challenging pathogens.
• The piezoelectric activatable nanozyme-based skin patch presents a promising strategy for advanced wound disinfection.