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Updated: Sep 21, 2025

Measurements of Physiological Stress Responses in C. Elegans
Published on: May 21, 2020
Genetically Programming Stress-Relaxation Behavior in Entirely Protein-Based Molecular Networks
Zhongguang Yang1, Songzi Kou2, Xi Wei3
1Department of Chemical and Biological Engineering and Center of Systems Biology & Human Health, The Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong SAR, China.
Abstract:
We report the synthesis of a series of elastin-like polypeptide (ELP)-based molecular networks through the combined use of the covalent bond-forming SpyTag/SpyCatcher chemistry, physically entangled p53dim domains (Xs), and site-directed mutagenesis. The resulting networks shared similar chemical composition but differed significantly in their viscoelasticity. These materials exhibited excellent compatibility toward encapsulated fibroblasts and stem cells. These results point to a versatile strategy for designing viscoelastic materials by tapping into diverse protein-protein interactions.
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