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Updated: Sep 21, 2025

Immunometabolic Circuits in Infection for Advancing Host Directed Therapies
Published on: September 13, 2024
Integrative understanding of immune-metabolic interaction
Seonyoung Im1, Hawon Kim1, Myunghyun Jeong1
1Department of Systems Biology, Yonsei University, Seoul 03722, Korea.
Abstract:
Recent studies have revealed that the immune system plays a critical role in various physiological processes beyond its classical pathogen control activity. Even under a sterile condition, various cells and tissues can utilize the immune system to meet a specific demand for proper physiological functions. Particularly, a strong link between immunity and metabolism has been identified. Studies have identified the reciprocal regulation between these two systems. For example, immune signals can regulate metabolism, and metabolism (cellular or systemic) can regulate immunity. In this review, we will summarize recent findings on this reciprocal regulation between immunity and metabolism, and discuss potential biological rules behind this interaction with integrative perspectives. [BMB Reports 2022; 55(6): 259-266].
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