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Gilles Berrut, Nicolas Piriou, Anne Sophie Boureau

    Geriatrie Et Psychologie Neuropsychiatrie Du Vieillissement
    |June 2, 2022
    PubMed
    Summary
    This summary is machine-generated.

    Cardiac amyloidosis, once rare, now affects 20% of those over 75. New treatments stabilize transthyretin, offering hope for senile cardiac amyloidosis patients.

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    Area of Science:

    • Cardiology
    • Geriatrics
    • Medical Diagnostics

    Background:

    • Senile cardiac amyloidosis, previously considered rare, is now recognized as prevalent in older adults.
    • Amyloidosis diagnosis historically lacked specific therapeutic options beyond managing heart failure and conduction issues.

    Purpose of the Study:

    • To highlight the increasing prevalence and diagnostic significance of senile cardiac amyloidosis.
    • To introduce emerging therapeutic strategies for transthyretin amyloidosis.
    • To emphasize the need for increased awareness among cardiologists and geriatricians.

    Main Methods:

    • Utilizing non-invasive diagnostic tools and autopsy studies to determine prevalence.
    • Reviewing advancements in therapeutic interventions targeting transthyretin stabilization and production.

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  • Examining the role of new drugs in clinical trials for cardiac amyloidosis.

    • Main Results:

    • Prevalence of cardiac amyloidosis estimated at approximately 20% in individuals over 75 years old.
    • New treatments demonstrate potential in stabilizing transthyretin and reducing amyloid-depositing oligomers.
    • Investigational drugs (anti-sense and oligonucleotides) show promise in blocking transthyretin production.

    Conclusions:

    • Cardiac amyloidosis diagnosis and management are evolving into standard clinical practice.
    • Cardiologists and geriatricians must be knowledgeable about cardiac amyloidosis for early and effective patient management.
    • Emerging therapies offer new avenues for treating senile cardiac amyloidosis.