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Published on: February 5, 2020
l-Asparaginase Encapsulation into Asymmetric Permeable Polymersomes
Cecilia Z Bueno1,2, Alexsandra C Apolinário1,3,2, Aroa Duro-Castano2
1Department of Biochemical and Pharmaceutical Technology, University of São Paulo, 05508-000 São Paulo, Brazil.
Abstract:
This work reports, for the encapsulation of l-asparaginase, an anticancer enzyme into hybrid PMPC25-PDPA70/PEO16-PBO22 asymmetric polymersomes previously developed by our group, with loading capacities with over 800 molecules per vesicle. Enzyme-loaded polymersomes show permeability and capacity to hydrolyze l-asparagine, which is essential to cancer cells. The nanoreactors proposed in this work can be potentially used in further studies to develop novel therapeutic alternatives based on l-asparaginase.
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