Binder's syndrome: A narrative review

Area of Science:

• Craniofacial anomalies
• Medical genetics

Background:

• Binder's syndrome (BS) presents classical features, but diagnostic and treatment challenges are under-reported.
• A comprehensive review of BS literature is needed to address these gaps.

Purpose of the Study:

• To review the literature on Binder's syndrome (BS).
• To explore diagnostic and treatment challenges in BS.
• To evaluate the role of a multidisciplinary approach in managing BS.

Main Methods:

• A systematic literature search was conducted across major scientific databases.
• Keywords included "Maxillonasal dysplasia", "Binder syndrome", and "OMIM 155050".
• English-language articles published until June 2021 were reviewed.

Main Results:

• 145 relevant articles were selected from 958 publications.
• Most studies were case reports (42%) or case series (19%).
• Surgical techniques were the most frequently discussed topic (42%).

Conclusions:

• A multidisciplinary approach is crucial for managing Binder's syndrome.
• Further research is needed to establish clinical guidelines for BS management.