Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Bipolar Disorder01:30

Bipolar Disorder

152
Bipolar disorder is a chronic mental health condition marked by significant mood fluctuations, including episodes of mania and depression. Elevated energy levels, heightened mood or irritability, impulsive behavior, reduced sleep needs, rapid speech, racing thoughts, inflated self-esteem, and distractibility characterize mania. Individuals with bipolar disorder often alternate between depressive and manic states, with periods of emotional stability lasting an average of six months to a year.
152
Depression: Overview01:18

Depression: Overview

377
Depression is a prevalent mental illness marked by persistent sadness and lack of interest in previously enjoyable activities. It can take several forms, including major depression, persistent depressive disorder, and bipolar I and II disorders. Symptoms range from emotional changes like chronic worry to physical changes like sleep disturbances and suicidal thoughts. From a neurobiological perspective, depression is believed to be triggered by abnormalities in the brain's prefrontal cortex,...
377
Depressive Disorders: Etiology01:27

Depressive Disorders: Etiology

173
Depressive disorders result from a complex interplay of biological, psychological, and sociocultural factors, each contributing uniquely to the development and persistence of the condition. Understanding these factors provides critical insight into the multifaceted nature of depression.
Biological Factors in Depression
Biological predispositions significantly influence the risk of developing depressive disorders. Genetic studies highlight the role of variations in the serotonin transporter...
173
Personality Theory by Eysenck and Eysenck01:29

Personality Theory by Eysenck and Eysenck

688
Hans and Sybil Eysenck developed a widely recognized theory of personality, which emphasizes the role of temperament and genetically based differences in shaping individual traits. Their theory posits that biological factors primarily determine personality and can be understood through two main dimensions: extroversion/introversion and neuroticism/stability.
In the extroversion/introversion dimension, highly extroverted people are sociable, outgoing, and easily connect with others. In contrast,...
688
Mania and Antimanic Drugs: Overview01:24

Mania and Antimanic Drugs: Overview

331
Mania, a psychological condition characterized by elevated mood, increased energy, and reduced sleep need, is part of the bipolar disorder cycle. The exact cause of mania isn't entirely known, but it is thought to be a combination of genetic, environmental, and neurological factors. Bipolar disorder involves alternating manic and depressive episodes. Mood stabilizers like lithium, antipsychotics, and anticonvulsants help manage these episodes. Lithium carbonate is particularly effective as...
331
Borderline Personality Disorder01:25

Borderline Personality Disorder

145
Borderline Personality Disorder is a complex and multifaceted mental health condition characterized by pervasive instability in interpersonal relationships, self-image, emotions, and impulse control. This instability manifests in extreme emotional reactions, fear of abandonment, and self-destructive behaviors. The disorder significantly impacts daily functioning, often leading to distress in both personal and professional domains.
Genetic and Environmental Contributions
Borderline Personality...
145

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Transcranial direct current stimulation (tDCS) as an add-on treatment for restricted repetitive behaviors in autism spectrum disorder - An open-label prospective feasibility study.

Psychiatry research·2026
Same author

Regional, functional and transcriptomic decoding of multidimensional brain structure alterations in obsessive-compulsive disorder.

Nature communications·2026
Same author

Safety of Transcranial Direct Current Stimulation With a Programmable Ventriculoperitoneal Shunt: A Case Report.

The journal of ECT·2026
Same author

Resting-state functional connectivity alterations in obsessive-compulsive disorder: relationships between connectivity and clinical profiles in the Global OCD study.

Biological psychiatry. Cognitive neuroscience and neuroimaging·2026
Same author

Toward trustworthy clinical AI for obsessive-compulsive disorder: reliability, generalizability, and interpretability of a transformer model across the ENIGMA-OCD consortium.

medRxiv : the preprint server for health sciences·2026
Same author

Ketamine infusion combined with accelerated sequential theta burst stimulation in multi-therapy-resistant bipolar depression: A case report.

Asian journal of psychiatry·2026

Related Experiment Video

Updated: Sep 21, 2025

Developing a Rat Model for Bipolar Disorder
04:42

Developing a Rat Model for Bipolar Disorder

Published on: May 2, 2025

473

Emotion Processing Deficit in Euthymic Bipolar Disorder: A Potential Endophenotype.

Preethi V Reddy1, Saravanakumar Anandan1, Gopalkumar Rakesh2

  • 1Dept. of Psychiatry & Translational Psychiatry Laboratory, Cognitive Neurobiology Division, Neurobiology Research Centre, National Institute of Mental Health & Neurosciences, Bengaluru, Karnataka, India.

Indian Journal of Psychological Medicine
|June 3, 2022
PubMed
Summary
This summary is machine-generated.

Bipolar disorder patients and their high-risk relatives show facial emotion recognition deficits. High-risk individuals specifically struggle with labeling fear and anger, suggesting a potential endophenotype for bipolar disorder.

Keywords:
Bipolar disorderemotion processingendophenotypeface affecthigh-risk subjects

More Related Videos

An Olfactory Preference Test for Measuring Olfactory Hedonic Biases in Mouse Models of Depression
06:34

An Olfactory Preference Test for Measuring Olfactory Hedonic Biases in Mouse Models of Depression

Published on: July 11, 2025

251
Design and Implementation of an fMRI Study Examining Thought Suppression in Young Women with, and At-risk, for Depression
08:42

Design and Implementation of an fMRI Study Examining Thought Suppression in Young Women with, and At-risk, for Depression

Published on: May 19, 2015

10.9K

Related Experiment Videos

Last Updated: Sep 21, 2025

Developing a Rat Model for Bipolar Disorder
04:42

Developing a Rat Model for Bipolar Disorder

Published on: May 2, 2025

473
An Olfactory Preference Test for Measuring Olfactory Hedonic Biases in Mouse Models of Depression
06:34

An Olfactory Preference Test for Measuring Olfactory Hedonic Biases in Mouse Models of Depression

Published on: July 11, 2025

251
Design and Implementation of an fMRI Study Examining Thought Suppression in Young Women with, and At-risk, for Depression
08:42

Design and Implementation of an fMRI Study Examining Thought Suppression in Young Women with, and At-risk, for Depression

Published on: May 19, 2015

10.9K

Area of Science:

  • Neuroscience
  • Psychiatry
  • Cognitive Psychology

Background:

  • Emotion processing deficits are a core cognitive abnormality in bipolar disorder (BD) with endophenotype potential.
  • Specific impairments in emotion processing strategies in euthymic adult BD patients and high-risk (HR) individuals compared to healthy controls (HCs) are not well-documented.

Purpose of the Study:

  • To examine facial emotion recognition deficits (FERD) in BD patients, HR subjects, and HCs.
  • To investigate specific emotion processing strategy impairments in these groups.

Main Methods:

  • Utilized the computer-administered face emotions-Matching And Labeling Task (eMALT).
  • Compared FERD in BD (N=30), HR (N=21), and HC (N=30) groups matched for age, education, and sex.

Main Results:

  • Significant differences were found in labeling accuracy for fear/anger (FA) and sad/disgust (SD) emotions across the three groups.
  • HR subjects showed significant deficits in labeling FA facial emotions compared to HCs.
  • BD patients exhibited significant differences in matching and labeling FA and SD emotions.

Conclusions:

  • Bipolar disorder in remission is associated with general FERD.
  • Specific labeling deficits for fear and anger in HR subjects suggest an impaired higher-order emotion processing aspect, potentially serving as an endophenotype for BD.
  • These deficits may indicate frontolimbic circuitry impairment and have implications for BD pathogenesis, functional recovery, and prognosis.