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Author Spotlight: Advancing Prostate Cancer Research Through Improved Tissue Sampling and Biobanking

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Published on: November 17, 2023

Testosterone analysis in prostate cancer patients.

Lennart J van Winden¹, Huub H van Rossum¹

¹Department of Laboratory Medicine, Netherlands Cancer Institute, Amsterdam, The Netherlands.

Advances in Clinical Chemistry

|June 6, 2022

Summary

This review covers testosterone regulation and androgen deprivation therapy for prostate cancer. It examines evolving testosterone testing methods for monitoring castration resistance, crucial for effective treatment.

Keywords:

Castration Immunoassay Liquid chromatography tandem-mass spectrometry Monitoring biomarker Prostate cancer Testosterone

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Area of Science:

Endocrinology
Oncology
Clinical Chemistry

Background:

Testosterone is a key steroid hormone influencing biological processes and driving prostate cancer growth via androgen signaling.
Androgen deprivation therapy (ADT) aims to deplete testosterone, slowing tumor progression before castration resistance develops.
Current methods for measuring castrate testosterone levels are outdated and debated, especially with new assay technologies.

Purpose of the Study:

To review testosterone regulation and ADT in prostate cancer.
To provide an overview of evolving testosterone analysis methods for monitoring castration and resistance.
To discuss current clinical practices, future utility, and provide recommendations for testosterone testing.

Main Methods:

Literature review of testosterone regulation, ADT, and testosterone assay development.
Analysis of current clinical practices and emerging mass spectrometry-based testosterone assays.
Discussion of the clinical utility and research implications of improved testosterone measurement.

Main Results:

ADT is a cornerstone in managing prostate cancer by reducing androgen signaling.
Existing testosterone assays for monitoring castration are suboptimal, leading to clinical debate.
Newer mass spectrometry assays offer improved sensitivity and specificity for testosterone measurement.

Conclusions:

Accurate testosterone monitoring is critical for effective ADT in prostate cancer.
Advancements in testosterone assay technology are essential for reliable clinical decision-making.
Standardized, validated testosterone assays are needed to guide prostate cancer therapy and research.