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Updated: Sep 20, 2025

Co-analysis of Brain Structure and Function using fMRI and Diffusion-weighted Imaging

Co-analysis of Brain Structure and Function using fMRI and Diffusion-weighted Imaging

Published on: November 8, 2012

The developing brain structural and functional connectome fingerprint.

Judit Ciarrusta¹, Daan Christiaens², Sean P Fitzgibbon³

¹Department of Forensic and Neurodevelopmental Science, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, United Kingdom; Centre for the Developing Brain, School of Imaging Sciences & Biomedical Engineering, King's College London, London, United Kingdom; Center for Brain and Cognition (CBC), Universitat Pompeu Fabra, Barcelona, Spain.

Developmental Cognitive Neuroscience

|June 6, 2022

Summary

This summary is machine-generated.

Brain connectivity fingerprints are unique to individuals. This study shows that structural brain connectivity in neonates is stable and can identify individuals, unlike functional connectivity, which changes rapidly.

Keywords:

brain networks connectivity diffusion MRI functional MRI neonate preterm tractography

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Functional Calcium Imaging in Developing Cortical Networks

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Published on: October 22, 2011

Area of Science:

Neuroscience
Developmental Neuroscience
Brain Imaging

Background:

Individual uniqueness in the mature brain is linked to structural and functional connectivity patterns.
It remains unclear if these distinguishing brain characteristics are present at birth.

Purpose of the Study:

To investigate the presence of a developing brain fingerprint in preterm neonates.
To assess the stability of structural and functional brain connectivity in early life.

Main Methods:

Utilized neuroimaging data from the developing Human Connectome Project (dHCP).
Scanned preterm neonates twice during the perinatal period.
Analyzed structural and functional connectomes to determine individual identifiability.

Main Results:

62% of neonates were identifiable by the congruence of their later structural connectome to their initial connectivity matrix.
Functional connectome similarity between time points was low, with only 10% showing greater self-similarity.
Structural connectivity demonstrated higher stability compared to functional connectivity in early development.

Conclusions:

A stable structural connectome may serve as an early individual fingerprint in neonates.
The developing brain exhibits a relatively stable structural architecture supporting a dynamic functional connectome.
This stability is crucial for neonates acquiring new skills to adapt to their environment.