Related Experiment Video
Updated: Sep 20, 2025
08:41
Live Imaging and Quantification of Viral Infection in K18 hACE2 Transgenic Mice Using Reporter-Expressing Recombinant SARS-CoV-2
Published on: November 5, 2021
2.9K
Therapeutics to tackle Omicron outbreak
Vivek P Chavda1, Eswara Naga Hanuma Kumar Ghali2,3, Murali M Yallapu2,3
1Department of Pharmaceutics & Pharmaceutical Technology, LM College of Pharmacy, Ahmedabad, Gujarat, 380008, India.
Immunotherapy
|June 9, 2022
Abstract:
Tweetable abstract In this commentary, the authors have focused on the mutational impact of the Omicron variant on the current therapeutics to manage #COVID19.
Insights
The Omicron variant
Area of Science:
- Virology
- Immunology
- Pharmacology
Background:
- The emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Omicron variant presents a significant challenge to public health.
- Understanding the impact of Omicron's mutations on existing COVID-19 therapeutics is crucial for effective disease management.
Purpose of the Study:
- To analyze the mutational landscape of the Omicron variant.
- To evaluate the potential impact of these mutations on the efficacy of current COVID-19 therapeutic agents.
Main Methods:
- Review of genomic data for Omicron variant.
- Analysis of published literature on therapeutic efficacy against Omicron.
Main Results:
- Omicron possesses numerous mutations, particularly in the spike protein.
- These mutations may confer reduced susceptibility to certain monoclonal antibodies and antiviral drugs.
Conclusions:
- The mutational profile of Omicron may necessitate adjustments in therapeutic strategies for COVID-19.
- Ongoing monitoring of variant evolution and its impact on treatment effectiveness is essential.
Related Concept Videos
01:28Antimicrobial Effectiveness
179
The effectiveness of antimicrobial agents depends on various factors influencing their ability to eliminate microbial populations. Larger microbial populations require more time for complete eradication, emphasizing the importance of population size analysis when evaluating antimicrobial efficacy.Microbial resistance to antimicrobial agents varies significantly. Highly resilient microorganisms include endospores, gram-negative bacteria, and non-enveloped viruses, while prions are exceptionally...
179
01:16Drugs Used in Upper Respiratory Disorders: Overview
381
Upper respiratory tract disorders, including viral infections and allergic rhinitis, cause significant discomfort and disrupt daily life. Managing these conditions involves a variety of drugs, such as antihistamines, intranasal steroids, decongestants, antitussives, expectorants, and mucolytics. Specific examples of drugs in each category are provided.
Antihistamines (e.g., Benadryl) block histamines from binding. Histamines are chemicals released during an allergic reaction in the body. As a...
Antihistamines (e.g., Benadryl) block histamines from binding. Histamines are chemicals released during an allergic reaction in the body. As a...
381
02:49Cancer Therapies
8.0K
Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
8.0K
01:29Microorganisms in Medicine and Therapeutics
384
Microorganisms play a fundamental role in vaccine development, gene therapy, and therapeutic production. Their biological properties are harnessed to advance medicine and public health. Beyond immunization, microorganisms contribute to gut health, antibiotic synthesis, and genetic disease treatment.Live Attenuated and Inactivated VaccinesLive attenuated vaccines, such as the measles, mumps, and rubella (MMR) vaccine, utilize weakened forms of pathogens to closely resemble natural infections.
384
01:17Drugs Used in Lower Respiratory Disorders: Overview
636
Lower respiratory tract disorders present challenges that often require skilled and nuanced approaches for effective management. Common ailments, such as asthma and chronic obstructive pulmonary disease (COPD), have prompted the development of intricate treatment strategies involving bronchodilators and anti-inflammatory drugs, each tailored to ease breathing and revitalize the lungs.
Bronchodilators, the first step of respiration enhancement, come in various forms, each with its own mechanism...
Bronchodilators, the first step of respiration enhancement, come in various forms, each with its own mechanism...
636
01:26Cholinergic Antagonists: Therapeutic Uses
894
Antimuscarinic drugs have various therapeutic applications by inhibiting parasympathetic stimulation in different systems. Here are the key therapeutic uses of antimuscarinics:
Respiratory Tract: Ipratropium, aclidinium, and tiotropium treat asthma, chronic bronchitis, and chronic obstructive pulmonary disease (COPD). They protect against bronchoconstriction caused by irritants like cigarette smoke, sulfur dioxide, and ozone. They also help reduce nasopharyngeal...
Respiratory Tract: Ipratropium, aclidinium, and tiotropium treat asthma, chronic bronchitis, and chronic obstructive pulmonary disease (COPD). They protect against bronchoconstriction caused by irritants like cigarette smoke, sulfur dioxide, and ozone. They also help reduce nasopharyngeal...
894