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Development of Multifunctional Commercial Pure Titanium-Polyethylene Glycol Drug-Eluting Substrates with Enhanced
Monalisha Mohanta1, A Thirugnanam2
1Department of Biotechnology and Medical Engineering, National Institute of Technology Rourkela, Rourkela, Odisha, 769008, India.
Cardiovascular Engineering and Technology
|June 14, 2022
Summary
Researchers developed advanced drug-eluting stents (DES) using titanium and PEG. These novel stents show improved optical properties and prevent thrombus formation, addressing key clinical challenges in stent implants.
Area of Science:
- Biomaterials Engineering
- Nanotechnology
- Medical Device Development
Background:
- Developing advanced stent implants with superior material and optical properties, particularly metal-polymer composite drug-eluting stents (DES), remains a significant challenge in biomedical engineering.
- Current stent technologies often face limitations in biocompatibility, drug elution control, and long-term efficacy, necessitating innovative material solutions.
Purpose of the Study:
- To develop multifunctional metal-polymer composite drug-eluting substrates (DES) for stent applications using commercially pure titanium (cpTi) and polyethylene glycol (PEG).
- To engineer a novel stent material with enhanced optical properties and antithrombotic capabilities to address critical clinical challenges in cardiovascular interventions.
Main Methods:
- Surface modification of cpTi substrates using sodium hydroxide (NaOH) to create a nanoporous structure.
- Encapsulation of Aspirin (ASA) drug via intermolecular forces and subsequent coating with PEG (MW-20,000) through physical adsorption in a layer-by-layer assembly.
- Characterization of the developed cpTi-PEG DES using XRD, FTIR, SEM, optical bandgap analysis, contact angle measurements, antithrombotic, and drug release studies.
Main Results:
- SEM and XRD confirmed the formation of sodium titanate oxide with induced nano-features on the cpTi surface.
- FTIR analysis verified the successful incorporation of ASA and PEG functional groups onto the cpTi substrate.
- Drug release studies followed the Ritger-Peppas model, indicating super case II transport mechanisms (n > 1), and improved antithrombotic activity was observed with reduced blood clot formation around the cpTi-PEG DES.
Conclusions:
- The developed cpTi-PEG DES exhibit enhanced optical properties and demonstrate significant potential in preventing thrombus formation.
- These findings suggest that the multifunctional cpTi-PEG DES represent a promising advancement for overcoming primary clinical challenges associated with current stent implants.
