A Text Mining Protocol for Mining Biological Pathways and Regulatory Networks from Biomedical Literature

A biological pathway or regulatory network is a collection of molecular regulators which can activate the changes in cellular processes leading to an assembly of new molecules by series of actions among the molecules. There are three important pathways in system biology studies namely signaling pathways, metabolic pathways, and genetic pathways (or) gene regulatory networks. Recently, biological pathway construction from scientific literature is given much attention as the scientific literature contains a rich set of linguistic features to extract biological associations between genes and proteins. These associations can be united to construct biological networks. Here, we present a brief overview about various biological pathways, biomedical text resources/corpora for network construction and state-of-the-art existing methods for network construction followed by our hybrid text mining protocol for extracting pathways and regulatory networks from biomedical literature.