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Updated: Sep 7, 2025

Molecular and Immunologic Techniques in a Genetically Engineered Mouse Model of Gastrointestinal Stromal Tumor
Published on: May 2, 2022
Gastrointestinal Stromal Tumor: New Insights for a Multimodal Approach
Ashwyn K Sharma1, Teresa S Kim2, Sebastian Bauer3
1Department of Surgery, Division of Surgical Oncology, University of California San Diego, San Diego, CA, USA; Moores Cancer Center, University of California San Diego School of Medicine, 3855 Health Sciences Drive, Box 0987, La Jolla, CA 92093, USA.
Abstract:
Over the past 20 years, gastrointestinal stromal tumor (GIST) has evolved into an increasingly complex clinical entity with ever more challenges. While surgical resection is the gold standard, advancements in genetic testing, therapeutic options, immunotherapy, and management of metastatic disease necessitate a comprehensive, multimodal approach for these tumors. This chapter highlights the importance of genomic testing of GIST, the use of neoadjuvant and adjuvant therapy for localized disease, surgical principles for GIST, as well as current and new approaches for addressing metastatic disease.
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