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Related Experiment Video

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Imaging as a Pain Biomarker.

Alon Kashanian1, Evangelia Tsolaki2, James Caruso3

  • 1Department of Surgery, Donald and Barbara Zucker School of Medicine, Hofstra/Northwell, Manhasset, NY, USA. Electronic address: https://twitter.com/AlonKashanian.

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Summary

Researchers are exploring brain imaging (neuroimaging) to find objective biomarkers for chronic pain. These biomarkers could personalize pain treatment and accelerate research, especially given the opioid crisis.

Keywords:
BiomarkerChronic painDTIDiffusionFunctionalImagingMRIfMRI

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Area of Science:

  • Neuroscience
  • Radiology
  • Pain Medicine

Background:

  • The search for objective chronic pain biomarkers is accelerating.
  • Precision medicine and the opioid crisis drive the need for faster pain research.
  • Neuroimaging studies reveal brain alterations in chronic pain patients.

Purpose of the Study:

  • To provide a comprehensive literature review on identifying neuroimaging biomarkers for pain.
  • To summarize current investigative efforts in the field.
  • To highlight the potential of neuroimaging in pain research.

Main Methods:

  • Comprehensive literature search and review.
  • Analysis of neuroimaging studies investigating chronic pain.
  • Synthesis of findings on regional and network brain alterations.

Main Results:

  • Chronic pain is linked to alterations in specific brain regions.
  • Whole-brain network changes are observed in chronic pain.
  • These neuroimaging findings may serve as potential biomarkers.

Conclusions:

  • Neuroimaging offers promising avenues for identifying objective pain biomarkers.
  • Biomarkers could guide diagnosis, treatment response, and personalized pain management.
  • Continued research is crucial to validate and implement these neuroimaging biomarkers.