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Cardioprotection of High-Risk Individuals

Jenica N Upshaw1, Sharanya Mohanty1, Akash Rastogi1

  • 1Division of Cardiology, Tufts Medical Center, 800 Washington St, Boston, MA 02111, USA.

Heart Failure Clinics
|June 19, 2022
PubMed

Insights

Identifying high-risk patients is key for effective cardioprotective strategies. Dexrazoxane and other therapies may protect anthracycline-treated patients from heart failure, while managing cardiovascular disease is crucial for all cancer patients.

Area of Science:

  • Cardiology and Oncology
  • Cancer Therapeutics
  • Cardiovascular Risk Management

Background:

  • Cardiotoxicity is a significant concern with cancer therapies.
  • Identifying patients at high risk for cardiac events is crucial for effective intervention.
  • Pre-existing cardiovascular disease (CVD) is a known risk factor for cardiotoxicity.

Purpose of the Study:

  • To review cardioprotective strategies for cancer patients.
  • To identify specific therapies beneficial for high-risk populations.
  • To discuss the role of managing cardiovascular disease in mitigating cardiotoxicity.

Main Methods:

  • Literature review of cardioprotective strategies.
  • Analysis of risk factors for cardiac events in cancer patients.
  • Evaluation of specific drug classes and treatment modalities.

Main Results:

  • Dexrazoxane, liposomal formulations, continuous infusions, and neurohormonal antagonists show promise for cardioprotection in anthracycline-treated patients.
  • Prevalent CVD is a risk factor for cardiac events with anthracyclines, anti-HER2 therapy, radiation, and BCR-Abl inhibitors.
  • Evidence for cardioprotection in non-anthracycline therapies is limited, but risk factor optimization is recommended.

Conclusions:

  • Targeted cardioprotective strategies can maximize benefits for high-risk cancer patients.
  • Proactive management of cardiovascular disease and risk factors is essential for all cancer patients undergoing therapy.
  • Further research is needed to establish cardioprotective guidelines for non-anthracycline cancer treatments.

Keywords:
AnthracyclinesCardio-oncologyCardiovascular diseaseChemotherapyHeart failureRadiation

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