Psychosis and prenatal exposure to diethylstilbestrol

Over the past 10 years, increasing evidence has demonstrated mammalian brain development to be influenced by prenatal exposure to sex hormones. It seems possible that human behavioral abnormalities may be associated with prenatal exposure to diethylstilbestrol (DES). Relevant basic science and clinical reports are reviewed and four case reports of psychotic patients who were prenatally exposed to DES are presented.