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Small Bowel Transplantation In Mice

Small Bowel Transplantation In Mice

Published on: August 20, 2007

Pediatric intestinal transplantation.

Eliza J Lee¹, George V Mazariegos¹, Geoffrey J Bond¹

¹The Hillman Center for Pediatric Transplantation, Children's Hospital of Pittsburgh, University of Pittsburgh Medical Center, 4401 Penn Ave, 6FP, Pittsburgh, PA 15224, United States of America.

Seminars in Pediatric Surgery

|June 20, 2022

Summary

This summary is machine-generated.

Pediatric intestinal transplantation (ITx) offers improved survival and enteral autonomy for children with intestinal failure. This review covers ITx history, indications, immunosuppression, complications, and outcomes.

Keywords:

Immunosuppression Infection Intestinal failure Intestinal transplant Post-transplant lymphoproliferative disease Post-transplant outcomes

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Tissue Engineering of the Intestine in a Murine Model

Published on: December 1, 2012

Area of Science:

Pediatric surgery
Transplantation immunology
Gastroenterology

Background:

Intestinal transplantation (ITx) has evolved significantly since the 1960s.
Improvements in donor management, organ preservation, operative techniques, and immunosuppression have enhanced outcomes.
Pediatric patients with intestinal failure now have opportunities for enteral autonomy and long-term survival.

Purpose of the Study:

To review the history of intestinal transplantation and rehabilitation in pediatric patients.
To discuss current indications for ITx in children.
To outline immunosuppression strategies, post-operative complications, and outcomes.

Main Methods:

Literature review focusing on pediatric intestinal transplantation.
Synthesis of historical data and current clinical practices.
Analysis of outcomes and quality of life post-transplant.

Main Results:

Intestinal transplantation has progressed from experimental to a viable option for select pediatric cases.
Key factors influencing success include advancements in surgical techniques and immunosuppressive regimens.
Post-transplant management involves addressing common complications and monitoring long-term quality of life.

Conclusions:

Pediatric intestinal transplantation provides a life-saving option for children with intestinal failure.
Continued research and clinical experience are crucial for optimizing patient outcomes.
Multidisciplinary care is essential for managing complex ITx cases and improving long-term survival.