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Updated: Sep 6, 2025

The WATCHMAN Left Atrial Appendage Closure Device for Atrial Fibrillation
Published on: February 28, 2012
DOACs for stroke prevention in patients with AF and cancer
Dipal Mehta1, Daniel M Jones2, Avirup Guha3
1Clinical Haematology, Barts Cancer Centre, St. Bartholomew's Hospital, Barts Health NHS Trust, London, EC1A 7BE.
Abstract:
Stroke prophylaxis in atrial fibrillation is an important consideration in patients with cancer. However, there is little consensus on the choice of anticoagulation, due to the numerous difficulties associated with active cancer. Direct oral anticoagulants (DOACs) have been shown to be a promising option. Here, we conduct a simple cross-sectional analysis of 29 cancer patients receiving DOACs for stroke prophylaxis in atrial fibrillation at a tertiary-care institution in London. Our study demonstrates an encouraging efficacy and safety profile of DOACs used in this setting. We conclude by suggesting that, while DOACs may be useful, anticoagulation in cancer patients should continue to be individualised.
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