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Updated: Sep 6, 2025
14:14
Standardized Technique of Aortic Valve Re-implantation for Valve-sparing Aortic Root Replacement
Published on: December 11, 2017
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Personalised external aortic root support (PEARS) to stabilise an aortic root aneurysm.
John Pepper1, Cemil Izgi2, Tal J Golesworthy3
1Consultant Cardiac Surgeon, Royal Brompton and Harefield NHS Foundation Trust, Sydney Street, London, SW3 6NP.
The British Journal of Cardiology
|June 24, 2022
Summary
Personalised external aortic root support (PEARS) offers a low-risk alternative for patients with aortic root aneurysms. This valve-sparing procedure demonstrates promising survival rates and can be applied early in disease progression.
Area of Science:
- Cardiovascular Surgery
- Medical Devices
- Aortic Diseases
Background:
- Congenital aortic root aneurysms pose risks including regurgitation, dissection, rupture, and death.
- Aortic root replacement is a common treatment, but alternatives are sought.
Purpose of the Study:
- To evaluate the safety and efficacy of Personalised External Aortic Root Support (PEARS) using ExoVasc mesh implants.
- To assess early outcomes, survival, and re-operation rates in patients with dilated aortic roots.
Main Methods:
- A multi-centre, prospective cohort study included 117 consecutive patients receiving ExoVasc mesh implants between 2004 and 2017.
- Inclusion criteria: asymptomatic aortic root/sinus of Valsalva and ascending aorta dilatation (40-50 mm), age ≥16, no more than mild aortic regurgitation.
- Kaplan-Meier method was used to estimate survival and re-operation-free survival.
Main Results:
- One early death occurred in the cohort of 117 patients.
- 75% of patients had a length of stay within seven days.
- The study describes baseline and peri-operative characteristics and early postoperative outcomes.
Conclusions:
- Personalised External Aortic Root Support (PEARS) achieves valve-sparing objectives.
- PEARS is a low-risk, conservative option that can be used early in the disease process.
- PEARS complements more invasive procedures like valve-sparing or total root replacement.
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