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Peripheral neuronal changes in growth-retarded neonates: an ultrastructural study.
Obstetrics and Gynecology
|June 1, 1987
Summary
Intrauterine growth retardation (IUGR) significantly alters fetal peripheral nerve development. Growth-restricted neonates show nerve fiber damage and abnormal Schwann cells, unlike healthy infants.
Area of Science:
- Neuroscience
- Developmental Biology
- Pediatrics
Background:
- Intrauterine growth retardation (IUGR) is a critical condition affecting fetal development.
- Peripheral neuronal development is crucial for fetal health and long-term neurological function.
Purpose of the Study:
- To investigate the ultrastructural effects of IUGR on fetal peripheral neuronal elements.
- To identify specific changes in nerve fibers and Schwann cells associated with IUGR.
Main Methods:
- Transmission electron microscopy was used to examine preputial skin biopsies.
- Samples were obtained from ten neonates with IUGR and six normal controls.
Main Results:
- Growth-retarded neonates exhibited significant ultrastructural alterations in myelinated and unmyelinated nerve fibers.
- Observed changes included mitochondrial abnormalities, axoplasmic vacuoles, and nerve fiber degeneration.
- Abnormalities in Schwann cells, such as glycogen accumulation and endoplasmic reticulum dilatation, were noted in IUGR infants.
Conclusions:
- IUGR is associated with substantial ultrastructural damage to developing peripheral neuronal tissue.
- These findings highlight the detrimental impact of IUGR on fetal nerve development.