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Analyses of Proteinuria, Renal Infiltration of Leukocytes, and Renal Deposition of Proteins in Lupus-prone MRL/lpr Mice
Published on: June 8, 2022
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Essential Trace Element Status in Systemic Lupus Erythematosus: a Meta-analysis Based on Case-Control Studies
Hua Wang1,2, Xian-Bao Li1,2, Rong-Gui Huang1,2
1Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, Hefei, Anhui, China.
Biological Trace Element Research
|June 24, 2022
Summary
Systemic lupus erythematosus (SLE) patients show altered levels of essential trace elements. This meta-analysis found lower zinc and iron, and higher copper in SLE patients compared to healthy controls, highlighting potential roles in disease pathogenesis.
Area of Science:
- Immunology
- Nutritional Science
- Clinical Medicine
Background:
- Trace element homeostasis is crucial for immune system regulation and may influence systemic lupus erythematosus (SLE) development.
- Previous epidemiological studies on trace element levels in SLE patients and healthy controls (HCs) have yielded inconsistent results.
Approach:
- A comprehensive meta-analysis was conducted, systematically searching PubMed, Embase, and Web of Science databases until April 2022.
- Eleven studies involving 1262 subjects were included, adhering to PRISMA 2020 guidelines for meta-analysis reporting.
- Pooled standardized mean differences (SMDs) and 95% confidence intervals (CIs) were used to assess trace element levels.
Key Points:
- Significantly lower levels of zinc (Zn) and iron (Fe) were observed in SLE patients compared to HCs.
- Conversely, copper (Cu) levels were significantly higher in SLE patients than in HCs.
- Geographical analysis indicated lower Fe and Zn in Asian SLE patients and higher Cu in European SLE patients, while selenium (Se) showed no significant difference.
Conclusions:
- Systemic lupus erythematosus patients exhibit distinct alterations in essential trace element concentrations, specifically lower Zn and Fe, and elevated Cu.
- These findings underscore the potential involvement of Zn, Cu, and Fe in SLE pathogenesis.
- Further research is recommended to elucidate the underlying mechanisms of these trace elements in SLE.
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