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Annotating Cancer-Related Variants at Protein-Protein Interface with Structure-PPi

Miguel Vazquez1, Tirso Pons2

  • 1Genome Informatics Unit, Barcelona Supercomputing Center (BSC-CNS), Barcelona, Spain. miguel.vazquez.g@bsc.es.

Methods in Molecular Biology (Clifton, N.J.)
|June 25, 2022
PubMed
Summary

Structure-PPi analyzes cancer variants using protein 3D structures and functional sites. This tool aids in distinguishing false-positive predictions and provides biological insights into variant roles in cancer.

Keywords:
3D structure analysisCancer mutationsProtein isoformsProtein–protein interactionsRbbt workflowsVariants prioritization

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