New PET Tracers: Current Knowledge and Perspectives in Lung Cancer
Marie M K Krarup1, Barbara M Fischer2, Tine N Christensen1
1Department of Clinical Physiology and Nuclear Medicine, Rigshospitalet Copehagen University Hospital, Copenhagen, Denmark.
Seminars in Nuclear Medicine
|June 25, 2022
Summary
New positron emission tomography (PET) tracers show promise for lung cancer diagnosis beyond standard 2-[18F]fluoro-2-deoxy-D-glucose ([18F]FDG) PET/CT scans. While not replacing current methods, these novel tracers offer supplementary insights into tumor biology and heterogeneity.
Area of Science:
- Nuclear Medicine
- Oncology
- Radiochemistry
Background:
- 18F]FDG-PET/CT is standard for lung cancer management but has limitations.
- Lung cancer remains a leading cause of cancer death with high recurrence rates.
- There is a need for more sensitive and specific PET tracers for improved lung cancer diagnosis and treatment.
Purpose of the Study:
- To review current knowledge and future perspectives of novel PET tracers for lung cancer.
- To discuss tracers targeting specific tumor characteristics and hallmarks of cancer.
Main Methods:
- Literature search of PubMed and clinicaltrials.gov (past decade).
- Exclusion of case reports, preclinical studies, and established tracers ([18F]FDG, DOTATE).
- Evaluation of relevant studies on new PET tracers for lung cancer.
Main Results:
- Several new PET tracers targeting cancer hallmarks have been developed.
- Some tracers show promise but require further clinical validation.
- No new tracer currently replaces [18F]FDG-PET/CT for lung cancer.
Conclusions:
- Novel PET tracers may serve as supplementary tools in lung cancer management.
- These tracers can provide deeper insights into tumor biological characteristics.
- They have the potential to visualize intra- and inter-tumoral heterogeneity, aiding personalized treatment strategies.
Related Concept Videos
01:29Positron Emission Tomography
5.3K
Positron emission tomography (PET) is a medical imaging technique involving radiopharmaceuticals — substances that emit short-lived radiation. Although the first PET scanner was introduced in 1961, it took 15 more years before radiopharmaceuticals were combined with the technique and revolutionized its potential.
One of the main requirements of a PET scan is a positron-emitting radioisotope, which is produced in a cyclotron and then attached to a substance used by the part of the body...
One of the main requirements of a PET scan is a positron-emitting radioisotope, which is produced in a cyclotron and then attached to a substance used by the part of the body...
5.3K
01:25Imaging Studies II: Positron Emission Tomography and Scintigraphy
233
Positron Emission Tomography (PET) is a medical imaging technique that provides crucial insights into the body's physiological functions at a molecular level. It is an indispensable resource for diagnosing, staging, and monitoring various illnesses, notably cancer, neurological disorders, and cardiovascular conditions.
Fundamental Principles of PET
Fundamental Principles of PET
233
01:13Radiological Investigation III: Pulmonary Angiogram and PET Scan
165
Radiological investigations are paramount in the diagnosis and management of various pulmonary diseases. Two essential investigations are the Pulmonary Angiogram and the Positron Emission Tomography (PET) Scan.
Pulmonary Angiogram
A Pulmonary Angiogram is an invasive procedure involving injecting a contrast medium through a catheter threaded into the pulmonary artery or the right side of the heart to visualize the pulmonary vasculature. Computed Tomography (CT) scans have mainly replaced this...
Pulmonary Angiogram
A Pulmonary Angiogram is an invasive procedure involving injecting a contrast medium through a catheter threaded into the pulmonary artery or the right side of the heart to visualize the pulmonary vasculature. Computed Tomography (CT) scans have mainly replaced this...
165