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Related Experiment Video

Updated: Sep 6, 2025

A Standardized Liquid Biopsy Preanalytical Protocol for Downstream Circulating-Free DNA Applications

A Standardized Liquid Biopsy Preanalytical Protocol for Downstream Circulating-Free DNA Applications

Published on: September 16, 2022

Liquid Biopsies: Flowing Biomarkers.

Vincent Hyenne^1,2,3,4,5, Jacky G Goetz^1,2,3,4, Naël Osmani^6,7,8,9

¹INSERM UMR_S1109, Strasbourg, France.

Advances in Experimental Medicine and Biology

|June 27, 2022

Summary

Liquid biopsies, using circulating tumor cells (CTCs) and extracellular vesicles (EVs), offer a non-invasive method to track cancer progression and treatment effectiveness. These biomarkers provide valuable insights for personalized medicine and prognosis.

Keywords:

Biomarker CTC (circulating tumor cell)Extracellular vesicle Liquid biopsy Metastasis

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Last Updated: Sep 6, 2025

A Standardized Liquid Biopsy Preanalytical Protocol for Downstream Circulating-Free DNA Applications

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Published on: September 16, 2022

Detection of Cell-Free DNA in Blood Plasma Samples of Cancer Patients

Detection of Cell-Free DNA in Blood Plasma Samples of Cancer Patients

Published on: September 9, 2020

Automatic Separation and Collection of Cancer-Related Substances from Clinical Samples

Automatic Separation and Collection of Cancer-Related Substances from Clinical Samples

Published on: January 13, 2023

Area of Science:

Oncology
Biomarker Discovery
Translational Medicine

Background:

Metastatic cancer progression is a leading cause of death.
Identifying reliable cancer biomarkers is crucial for treatment assessment.
Liquid biopsies offer a minimally invasive alternative to traditional tumor biopsies.

Purpose of the Study:

To highlight the potential of circulating tumor cells (CTCs) and extracellular vesicles (EVs) as cancer biomarkers.
To discuss the role of CTC adhesive and mechanical properties in metastasis.
To review recent advancements in EV isolation and biomarker identification for cancer prognosis.

Main Methods:

Analysis of circulating tumor cells (CTCs) and extracellular vesicles (EVs) from biofluids.
Characterization of membrane surface repertoire and molecular content of CTCs and EVs.
Evaluation of adhesive and mechanical properties of CTCs.
Review of novel EV isolation techniques and biomarker discovery.

Main Results:

CTCs and EVs show significant potential as cancer biomarkers.
Adhesive and mechanical properties of CTCs can serve as metastatic markers.
Advancements in EV isolation are enabling the identification of new biomarkers.
Liquid biopsies facilitate longitudinal monitoring for treatment response and relapse.

Conclusions:

Liquid biopsies, through CTCs and EVs, represent a powerful tool in oncology.
These biomarkers are instrumental for personalized medicine, enabling treatment monitoring and relapse prediction.
Further research into CTCs and EVs will enhance their utility in cancer prognosis and management.