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[Expression of thyroglobulin antibody and thyroid peroxidase antibody in children with immune thrombocytopenia]
Xue-Mei Wang1, Hailigulli Nuriddin1, Yu Liu1
1First Department of Internal Pediatrics, First Affiliated Hospital of Xinjiang Medical University, Urumqi 830054, China.
Insights
Thyroglobulin antibody (TGAb) and thyroid peroxidase antibody (TPOAb) are elevated in children with immune thrombocytopenia (ITP). These autoantibodies correlate with ITP classification, aiding in diagnosis.
Area of Science:
- Pediatric Immunology
- Autoimmunity Research
- Hematology
Background:
- Immune thrombocytopenia (ITP) is an autoimmune disorder characterized by low platelet counts.
- Autoantibodies, including TGAb and TPOAb, are implicated in various autoimmune conditions.
- Understanding autoantibody expression in pediatric ITP is crucial for diagnosis and management.
Purpose of the Study:
- To investigate the expression levels of serum TGAb and TPOAb in children diagnosed with ITP.
- To analyze the association between TGAb and TPOAb expression and the clinical classification of ITP in pediatric patients.
Main Methods:
- A comparative study involving 120 children with ITP and 60 healthy controls.
- Classification of ITP patients into newly diagnosed, persistent, and chronic groups.
- Measurement of serum TGAb, TPOAb, and immune cell markers (CD3+, CD4+, CD8+), along with platelet counts.
Main Results:
- Children with ITP exhibited significantly higher levels of TGAb and TPOAb compared to controls.
- Elevated TGAb and TPOAb levels were notably higher in the chronic ITP subgroup.
- Logistic regression identified TGAb, TPOAb, and specific T-cell markers as significant factors influencing chronic ITP.
Conclusions:
- Abnormal expression of TGAb and TPOAb is evident in pediatric ITP.
- Serum TGAb and TPOAb levels are associated with the clinical classification of ITP in children.
- Combined TGAb and TPOAb assessment may aid in evaluating ITP clinical classification.
Objectives:
To examine the expression of serum thyroglobulin antibody (TGAb) and thyroid peroxidase antibody (TPOAb) in children with immune thrombocytopenia (ITP).
Methods:
A total of 120 children with ITP who were admitted from October 2019 to October 2021 were enrolled as the ITP group. A total of 60 children without ITP were enrolled as the non-ITP group. According to the clinical classification of ITP, the children in the ITP group were further divided into a newly diagnosed ITP group, a persistent ITP group, and a chronic ITP group. The clinical data were compared between the ITP group and the non-ITP group and between the children with different clinical classifications of ITP. The expression levels of serum TGAb and TPOAb in children with ITP were measured and their association with the clinical classification of ITP was analyzed.
Results:
Compared with the non-ITP group, the ITP group had significantly lower levels of CD3+, CD4+, and platelet count (PLT) and significantly higher levels of CD8+, TGAb, and TPOAb (P<0.05). The children with chronic ITP had significantly lower levels of CD3+, CD4+, and PLT and significantly higher levels of CD8+, TGAb, and TPOAb than those with newly diagnosed ITP or persistent ITP (P<0.05). The logistic regression analysis showed that CD3+, CD4+, CD8+, TGAb, and TPOAb were the influencing factors for chronic ITP (P<0.05). A decision curve was plotted, and the results showed that TGAb combined with TPOAb within the high-risk threshold range of 0.0-1.0 had a net benefit rate of >0 in evaluating the clinical classification of ITP in children.
Conclusions:
TGAb and TPOAb are abnormally expressed in children with ITP and are associated with the clinical classification of ITP in children.
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