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Published on: September 8, 2023
Autopsy case of a patient with rapidly progressive combined small-cell lung carcinoma with spindle-shaped cell tumor
Toshiki Morimoto1, Kei Yamasaki1, Tatsuya Shingu1
1Department of Respiratory Medicine, University of Occupational and Environmental Health, Kitakyushu City, Japan.
Abstract:
A 69-year-old Japanese man visited our hospital because of worsening shortness of breath. His chest computed tomography (CT) showed a giant left lung mass with a massive left pleural effusion. He could not be treated with chemotherapy and eventually died from a rapidly progressive tumor. He was diagnosed with combined small cell lung carcinoma (C-SCLC) with spindle-shaped cell tumor at autopsy. C-SCLC is characterized by pathologically concurrent SCLC and adenocarcinoma or squamous cell carcinoma, or rarely, spindle-shaped cell tumor. The clinical course of C-SCLC with spindle-shaped cell tumor has not previously been determined. Our patient's tumor increased by 2.59-fold in 20 days. The combination of C-SCLC with spindle-shaped cell tumor suggested rapid progression and a poor prognosis.
