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Pascal Houzé, Nouzha Djebrani Oussedik, Quentin Raimbourg

    Annales De Biologie Clinique
    |June 29, 2022
    PubMed
    Summary
    This summary is machine-generated.

    A woman developed acute kidney injury and rhabdomyolysis after consuming a black stone for COVID-19 protection. Analysis revealed the stone contained over 99% paraphenylenediamine (PPD), a toxic chemical.

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    Area of Science:

    • Toxicology
    • Clinical Chemistry
    • Public Health

    Background:

    • Social media promotes unverified health remedies.
    • Ingestion of unknown substances poses significant health risks.
    • Paraphenylenediamine (PPD) is a known toxicant found in hair dyes.

    Purpose of the Study:

    • To identify the toxic agent in a "black stone" consumed for COVID-19 prevention.
    • To investigate the clinical presentation and laboratory findings of PPD intoxication.
    • To highlight the dangers of unverified health advice circulating on social media.

    Main Methods:

    • Clinical examination and biological workup of a patient with acute symptoms.
    • Toxicological analysis of the ingested "black stone" using ICP-MS, GC-MS, and UV spectroscopy.

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  • Analysis of patient plasma for toxic compounds.

    • Main Results:

    • The patient presented with acute kidney injury and rhabdomyolysis.
    • The "black stone" was identified as over 99% pure paraphenylenediamine (PPD).
    • PPD was not detected in the patient's plasma due to analytical limitations and time delay.

    Conclusions:

    • Consumption of PPD-containing "black stones" can lead to severe toxic effects, including kidney failure and muscle breakdown.
    • The study underscores the critical need for public awareness regarding the dangers of ingesting unverified substances promoted online.
    • Healthcare providers should consider PPD toxicity in patients presenting with unexplained rhabdomyolysis and acute kidney injury, especially with a history of consuming unusual substances.