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Related Concept Videos

Inflammatory Response01:28

Inflammatory Response

6.8K
An inflammatory response is a localized, nonspecific immune reaction that occurs when a tissue is injured. It is characterized by redness, swelling, heat, and pain, which are commonly called the cardinal signs and symptoms of inflammation. Inflammation can sometimes result in a loss of function.
Inflammation can be triggered by various stimuli, such as impact, abrasion, chemical irritation, infections, and extreme hot or cold temperatures. These can damage cells and connective tissue fibers,...
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Inflammatory Response I: Vascular and Cellular01:30

Inflammatory Response I: Vascular and Cellular

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The inflammatory response is the body's defense against infection, injury, or irritation from bacteria, trauma, toxins, or heat. Inflammation helps locate and destroy pathogens and remove damaged tissue elements to heal the body. During this initial phase, fluid, blood products, and nutrients migrate to the injured area, resulting in redness, heat, swelling, ache, and loss of function. Moreover, signs of systemic inflammation include fever, increased WBC count, malaise, anorexia, nausea,...
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Inflammatory Response II: Inflammatory Exudate and Tissue Repair01:24

Inflammatory Response II: Inflammatory Exudate and Tissue Repair

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The immune system's inflammatory response destroys the invading pathogen, permitting the tissue to heal. The changes during the cellular and vascular stages allow exudate formation at the site of inflammation. The inflammatory exudate released from the wound has high protein content and a specific gravity above 1.020.
The typical wound exudate is odorless, transparent, straw-colored, thin, and watery. Exudate, however, can differ depending on the state of wound healing. Likewise, the...
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Inflammation01:38

Inflammation

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Overview
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Vascular Spasm01:16

Vascular Spasm

1.8K
The vascular phase, also known as vasospasm, is the initial stage of hemostasis, crucial for preventing excessive bleeding when a blood vessel is injured. After a vessel is cut, nerves in the damaged area trigger pain and other sensory impulses. Simultaneously, the smooth muscles in the vessel wall contract, resulting in a vascular spasm. This contraction reduces the vessel's diameter at the injury site, slowing or stopping blood loss through the vessel wall. Vascular spasms typically last...
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Related Experiment Video

Updated: Sep 6, 2025

Isolation and Flow Cytometric Analysis of Immune Cells from the Ischemic Mouse Brain
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Isolation and Flow Cytometric Analysis of Immune Cells from the Ischemic Mouse Brain

Published on: February 12, 2016

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Inflammatory Responses After Ischemic Stroke.

Jonathan Howard DeLong1, Sarah Naomi Ohashi1, Kevin Charles O'Connor1

  • 1Departments of Neurology and Immunobiology, Yale University School of Medicine, New Haven, CT, USA.

Seminars in Immunopathology
|June 29, 2022
PubMed
Summary
This summary is machine-generated.

Ischemic stroke triggers an immune response impacting brain repair and neuronal loss. This review summarizes recent advances in understanding the inflammatory process and developing new therapeutics for stroke patients.

Keywords:
BrainInflammationIschemic strokeLeukocyteNeurotoxicReparative

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Area of Science:

  • Neuroscience
  • Immunology
  • Pathophysiology

Background:

  • Ischemic stroke initiates a complex immune response involving diverse cell types and molecules, affecting both central nervous system (CNS) and peripheral tissues.
  • Existing reviews on this topic are several years old, necessitating an update on recent significant discoveries in the field.
  • The immune response post-stroke plays a dual role, contributing to both neuronal damage and subsequent tissue repair processes.

Purpose of the Study:

  • To provide a high-level overview of the current state of knowledge regarding the immune response following ischemic stroke.
  • To examine the initiation and progression of the inflammatory cascade after stroke.
  • To discuss the multifaceted impact of leukocytes on patient outcomes and explore therapeutic potential derived from basic science research.

Main Methods:

  • Comprehensive literature search of PubMed database to identify recent research advances.
  • Systematic review and synthesis of information on the inflammatory response in ischemic stroke.
  • Unbiased analysis of current findings to reflect the overall state of the field.

Main Results:

  • Recent discoveries have elucidated the intricate mechanisms of inflammatory response initiation after ischemic stroke.
  • The role of leukocytes in stroke pathogenesis and recovery is complex, with significant implications for patient outcomes.
  • Advances in basic science offer promising avenues for the development of novel therapeutic strategies.

Conclusions:

  • Understanding the immune response to ischemic stroke is critical for improving patient outcomes.
  • Further research into the identified knowledge gaps holds potential for advancing stroke therapies.
  • Translating basic science discoveries into effective clinical treatments remains a key objective.