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Updated: Sep 6, 2025
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Irradiator Commissioning and Dosimetry for Assessment of LQ α and β Parameters, Radiation Dosing Schema, and in vivo Dose Deposition
Published on: March 11, 2021
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Practice changing data and emerging concepts from recent radiation therapy randomised clinical trials.
Sophie Espenel1, Cyrus Chargari2, Pierre Blanchard3
1Gustave Roussy, Département de Radiothérapie, F-94805, Villejuif, France.
European Journal of Cancer (Oxford, England : 1990)
|July 2, 2022
Summary
Recent oncology randomized clinical trials (RCTs) show advancements in radiation therapy, including new drug combinations, personalized treatments, and hypofractionated schemes, improving patient outcomes and quality of life.
Area of Science:
- Oncology
- Radiation Therapy
- Clinical Trials
Background:
- Oncology treatments are rapidly evolving.
- Radiation therapy research is dynamic and impacts therapeutic standards.
- Recent randomized clinical trials (RCTs) are crucial for evaluating new strategies.
Purpose of the Study:
- To highlight the latest practice-changing radiation therapy trials.
- To provide an overview of emerging concepts in radiation oncology.
- To identify recent randomized clinical trials (RCTs) in radiation therapy.
Main Methods:
- Searched Medline database for radiation therapy RCTs published between 2018 and 2021.
- Identified publications reporting on randomized clinical trials in radiation therapy.
- Focused on trials published within a specific four-year period.
Main Results:
- Newer combinatorial strategies (radioimmunotherapy, pro-apoptotic agents, nanoparticles) show promise in various cancers.
- Advanced radiotherapy techniques like stereotactic body radiotherapy are expanding indications.
- Personalized radiation therapy using imaging (PET-CT, MRI) and biomarkers (PSA, HPV) is leading to tailored treatments.
- (Ultra)hypofractionated schemes are validated across multiple cancer types, offering equivalent outcomes with improved patient convenience.
- Patient quality of life and satisfaction are increasingly prioritized.
Conclusions:
- Radiation therapy research is dynamic, with numerous RCTs significantly impacting treatment standards.
- Investment in radiotherapy research is essential for translating innovations into clinical practice.
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