[Changes in the microflora of the large intestine in rats administered cephalexin and erythromycin orally]

The effect of long-term use of cephalexin and erythromycin (for 17 days) on large intestine microflora was studied on rats. It was found that intragastric administration of cephalexin in a dose of 800 mg/kg and erythromycin in a dose of 400 mg/kg was followed by changes in the quantitative and qualitative composition of the large intestine aerobic and anaerobic microflora. However, it did not induce production of beta-aspartyl glycine which is a biochemical indicator of deep changes in intestinal microflora. The long-term use of the above antibiotics resulted in increased levels and persistence of intestine colonization with facultative pathogenic enterobacteria and staphylococci resistant to the chemotherapeutic agents.