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Related Experiment Video

Updated: Sep 5, 2025

Optrode Array for Simultaneous Optogenetic Modulation and Electrical Neural Recording
06:36

Optrode Array for Simultaneous Optogenetic Modulation and Electrical Neural Recording

Published on: September 1, 2022

3.9K

Silicon optrode array with monolithically integrated SU-8 waveguide and single LED light source.

Daeho Ryu1, Youjin Lee2,3, Yongseung Lee1

  • 1Department of Electrical and Computer Engineering, Seoul National University, Seoul 08826, Republic of Korea.

Journal of Neural Engineering
|July 7, 2022
PubMed
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This summary is machine-generated.

This study introduces a novel silicon optrode array coupled with a light-emitting diode (LED) and polymer waveguide. This device enables efficient optical stimulation and neural recording in the hippocampus.

Area of Science:

  • Neuroscience
  • Biomedical Engineering
  • Optoelectronics

Background:

  • Optogenetic neuromodulation requires efficient light delivery systems.
  • Existing systems often face challenges with power consumption and light coupling efficiency.
  • Silicon optrode arrays are crucial for neural recording.

Purpose of the Study:

  • To develop a novel light-emitting diode (LED) and polymer waveguide coupled silicon optrode array.
  • To enhance light coupling efficiency and reduce power consumption for wireless optogenetic systems.
  • To demonstrate simultaneous optical stimulation and neural signal recording.

Main Methods:

  • Fabrication of a lensed waveguide using SU-8 photoresist with a plano-convex lens.
  • Integration of a cylindrical lens to focus light in the vertical direction.
Keywords:
LEDMEMSSU-8 waveguidein-vivooptogeneticssilicon optrode

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  • Assembly of a 1x4 optrode array with a 465 nm LED and iridium oxide (IrO2) electroplated recording electrodes.

    • Main Results:

    • The integrated lens system increased light coupling efficiency by 6.7 dB (cylindrical lens) and 6.6 dB (plano-convex lens).
    • The optrode array delivered a light intensity of approximately 2.7 mW/mm² at the waveguide outlet.
    • The iridium oxide recording electrodes exhibited an average impedance of 43.6 kΩ.

    Conclusions:

    • The developed LED and SU-8 waveguide coupled silicon optrode array successfully demonstrated in-vivo optical stimulation and neural recording in the hippocampus (CA1 and CA2 regions).
    • The system's design facilitates high light coupling efficiency and low power consumption, suitable for wireless applications.