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Frontopolar cortex shapes brain network structure across prefrontal and posterior cingulate cortex.

Matthew Ainsworth1, Zhemeng Wu2, Helen Browncross3

  • 1Department of Experimental Psychology, University of Oxford, Oxford OX1 3SR, United Kingdom; MRC Cognition and Brain Sciences Unit, University of Cambridge, 15 Chaucer Road, Cambridge, United Kingdom.

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Summary
This summary is machine-generated.

The frontopolar cortex (FPC) interacts with key brain regions, including the posterior cingulate and ventrolateral prefrontal cortex. Lesioning the FPC significantly disrupts functional connectivity in these areas, impacting decision-making processes.

Keywords:
FMRIFrontopolar cortexMacaquePrefrontal cortexResting-state connectivity

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Area of Science:

  • Neuroscience
  • Cognitive Neuroscience
  • Primate Brain Research

Background:

  • The frontopolar cortex (FPC), area 10, is functionally superior within the prefrontal cortex.
  • Its role in broader cortical networks remains largely unexplored.

Purpose of the Study:

  • To investigate the functional connectivity network associated with the primate FPC.
  • To identify specific cortical regions connected to the FPC using resting-state functional connectivity (rsfc).

Main Methods:

  • rsfc analysis was performed on rhesus monkeys.
  • Lesions were introduced to the FPC and neighboring principal sulcus cortex.
  • FPC-specific regions of interest (ROIs) were identified based on connectivity changes.

Main Results:

  • A distinct network of FPC-associated ROIs was identified.
  • Lesions to FPC, but not the principal sulcus, altered the connectivity of this network.
  • Core ROIs included ventrolateral prefrontal cortex, posterior cingulate cortex, and superior temporal gyrus.
  • FPC lesions profoundly disturbed functional connectivity in posterior cingulate and ventrolateral prefrontal cortex.

Conclusions:

  • The FPC, posterior cingulate cortex, and ventrolateral prefrontal cortex form an interacting network.
  • This network's interactions are crucial for the FPC's contribution to decision-making.