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Related Concept Videos

Cancer Stem Cells and Tumor Maintenance02:40

Cancer Stem Cells and Tumor Maintenance

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Early diagnosis and treatment can often cure cancer. However, even with treatment, residual cells called cancer stem cells (CSC) might remain, often causing tumor recurrence. These cancer stem cells possess the potential for self-renewal and multi-lineage differentiation and are often responsible for the therapeutic resistance displayed in most cancers.
Cancer stem cells are thought to originate from tissue-specific normal stem cells or progenitor cells. The normal stem cells usually reside in...
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Stem Cell Therapy for Tissue Regeneration01:21

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Stem cell therapy is a method used in regenerative medicine to repair and restore function to damaged tissues and organs. Stem cells have the potential to proliferate and differentiate into various tissue types, making them ideal candidates for tissue regeneration. For example, hematopoietic stem cell transplants are commonly used in blood cancer treatment to replenish damaged bone marrow and restore healthy blood cells.
Types of Stem Cells used in Stem Cell Therapy
The two main cell...
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EPS and iPS Cells in Disease Research01:21

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Embryonic and induced pluripotent stem cells are excellent models for disease research because of their ability to self-renew and differentiate into most cell types. Somatic cells from a patient are isolated and reprogrammed into induced pluripotent stem cells or iPSCs. These iPSCs are later differentiated into the desired cell type, which mirrors the diseased cell of the patient. In this way, disease models have been created for investigating diseases such as Down syndrome, type I diabetes,...
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Stem Cell Culture01:17

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Stem cell research aims to find ways to use stem cells to regenerate and repair cellular damage. Over time, most adult cells undergo the wear and tear of aging and lose their ability to divide and repair themselves. Stem cells do not display a particular morphology or function. Adult stem cells, which exist as a small subset of cells in most tissues, keep dividing and can differentiate into a number of specialized cells generally formed by that tissue. These cells enable the body to renew and...
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Mouse Models of Cancer Study

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Mice have long served as models for studying human biology and pathology because of their phylogenetic and physiological similarity with humans. They are also easy to maintain and breed in the laboratory, and hence, many inbred strains are now available for research. Studies on mice have contributed immeasurably to our understanding of cancer biology.
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Mesenchymal Stem Cells01:19

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Mesenchymal stem cells (MSCs) are adult stem cells that can differentiate into most connective tissue cell types, except for hematopoietic cells, depending upon the source of MSCs. For example, bone-marrow-derived MSCs (BM-MSCs) can differentiate into osteocytes, hepatocytes, and pancreatic and neuronal cells. MSCs can be isolated from various sources such as bone marrow, placenta, adipose tissue, teeth, and Wharton’s jelly, a gelatinous substance in the umbilical cord. The ease of their...
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Related Experiment Video

Updated: Sep 5, 2025

A Three-dimensional Model of Spheroids to Study Colon Cancer Stem Cells
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Stem Cell Models for Cancer Therapy.

Nitin Telang1

  • 1Cancer Prevention Research Program, Palindrome Liaisons Consultants, Montvale, NJ 07645-1559, USA.

International Journal of Molecular Sciences
|July 9, 2022
PubMed
Summary

Drug-resistant cancer stem cells drive metastatic breast and colon cancer. This review explores novel phytochemicals targeting these stem cells as potential therapies for resistant cancers.

Area of Science:

  • Oncology
  • Cancer Stem Cell Biology
  • Pharmacology

Background:

  • Metastatic breast and colon cancers in women are leading causes of mortality.
  • Therapy resistance is linked to drug-resistant cancer stem cell (CSC) populations.
  • CSCs promote metastasis through signaling pathway activation and epithelial-mesenchymal transition.

Purpose of the Study:

  • To review conceptual and experimental aspects of chemo-endocrine therapy for breast and colon cancer.
  • To discuss molecular and cellular characteristics of CSCs.
  • To explore phytochemicals as potential CSC-targeting agents for therapy-resistant cancers.

Main Methods:

  • Development of drug-resistant CSC models from breast and colon cancer cell lines.
  • Characterization of these CSCs by stem cell marker expression.
Keywords:
breast and colon cancerstem cellstestable therapeutic alternatives

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  • Utilizing CSC models to test the efficacy of dietary phytochemicals.

    • Main Results:

    • Drug-resistant CSCs are key drivers of therapeutic failure and metastasis.
    • Phytochemicals show potential as stem-cell-targeted agents.
    • Novel therapeutic strategies are needed for therapy-resistant breast and colon cancers.

    Conclusions:

    • Reliable CSC models are crucial for developing new cancer therapies.
    • Naturally occurring phytochemicals offer promising avenues for targeting CSCs.
    • Further research into stem-cell-targeting compounds is warranted for overcoming treatment resistance.