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Related Concept Videos

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Embryonic and induced pluripotent stem cells are excellent models for disease research because of their ability to self-renew and differentiate into most cell types. Somatic cells from a patient are isolated and reprogrammed into induced pluripotent stem cells or iPSCs. These iPSCs are later differentiated into the desired cell type, which mirrors the diseased cell of the patient. In this way, disease models have been created for investigating diseases such as Down syndrome, type I diabetes,...
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Mice have long served as models for studying human biology and pathology because of their phylogenetic and physiological similarity with humans. They are also easy to maintain and breed in the laboratory, and hence, many inbred strains are now available for research. Studies on mice have contributed immeasurably to our understanding of cancer biology.
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Stem Cell Models for Breast and Colon Cancer: Experimental Approach for Drug Discovery.

Nitin T Telang1

  • 1Cancer Prevention Research Program, Palindrome Liaisons Consultants, Montvale, NJ 07645-1559, USA.

International Journal of Molecular Sciences
|August 26, 2022
PubMed
Summary

Developing drug-resistant cancer stem cell models is crucial for discovering new breast and colon cancer therapies. These models help identify natural compounds that can target therapy-resistant cancer stem cells, offering new treatment alternatives.

Keywords:
breast and colon cancercancer stem cellstherapeutic alternatives

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Area of Science:

  • Oncology
  • Cancer Stem Cell Biology
  • Drug Discovery

Background:

  • Metastatic breast and colon cancer significantly contribute to female mortality.
  • Conventional and targeted therapies face challenges like drug resistance and off-target effects.
  • Chemotherapy resistance can lead to the emergence of therapy-resistant cancer stem cells responsible for disease progression.

Purpose of the Study:

  • To review the development and characterization of drug-resistant cancer stem cell models for breast and colon cancer.
  • To explore the potential of dietary phytochemicals and bioactive compounds as therapeutic alternatives.
  • To validate these models for novel drug discovery against therapy-resistant cancers.

Main Methods:

  • Systematic review of published evidence on cancer therapy and stem cell models.
  • Characterization of cellular and molecular markers in drug-resistant stem cell populations.
  • Evaluation of the efficacy of dietary phytochemicals against cancer stem cells.

Main Results:

  • Drug-resistant stem cell models demonstrate progressive growth despite cytotoxic therapeutics.
  • Upregulated expression of stem cell markers is observed in resistant cells.
  • Dietary phytochemicals and bioactive compounds show growth inhibitory effects on cancer stem cells.

Conclusions:

  • Reliable drug-resistant cancer stem cell models are essential for developing novel therapeutic strategies.
  • Naturally occurring agents offer promising avenues for targeting therapy-resistant breast and colon cancers.
  • Validated stem cell models are critical for advancing drug discovery platforms for resistant cancers.