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Related Concept Videos

Skin Cancer01:30

Skin Cancer

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Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
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Mutagenicity and Carcinogenicity01:25

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Mutagenicity and carcinogenicity refer to the ability of drugs to cause genetic defects and induce cancer, respectively. The International Agency for Research on Cancer (IARC) classifies agents into four groups based on their carcinogenic potential. Group 1 agents are known human carcinogens; group 2A agents are probably carcinogenic to humans; group 3 agents lack data to support their role in carcinogenesis; and group 4 includes agents for which data support that they are not likely to be...
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Classification of Epithelial Tissues: Glandular Epithelium01:20

Classification of Epithelial Tissues: Glandular Epithelium

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The glandular epithelium is made of one or more epithelial cells modified to synthesize and secrete chemical substances. Glandular epithelia can be classified based on cell number. Unicellular glands have individual secretory cells scattered across the epithelial monolayer. In contrast, multicellular glands consist of a hollow tubular duct attached to the cluster of secretory cells located in the deep pockets.
Multicellular glands are formed during early development when epithelial budding...
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Classification of Epithelial Tissues: Overview01:22

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Epithelial tissues are classified according to the shape of the cells and the number of cell layers formed. Cell shapes can be squamous (flattened and thin), cuboidal (square-like, as wide as it is tall), or columnar (rectangular, taller than it is wide). Additionally, the nucleus shape helps identify the type of epithelial cells. Squamous cells have flattened disc-shaped nuclei, cuboidal cells have spherical nuclei, and columnar cells have elongated nuclei.
Based on the number of cell layers,...
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Cancer Prevention02:59

Cancer Prevention

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Several factors can increase the risk of cancer in an individual. About 50% of cancer cases can be prevented by adopting a healthy lifestyle, regular exercise, eating healthy, and following a modest cancer prevention diet. Epidemiological studies have consistently shown that populations with vegetable and fruit-rich diets have reduced the incidence of cancer. On the other hand, populations who have a diet rich in animal fat, red meat, junk food, or high calories are predisposed to cancer.
Some...
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Cancers Originate from Somatic Mutations in a Single Cell02:21

Cancers Originate from Somatic Mutations in a Single Cell

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Cancer arises from mutations in the critical genes that allow healthy cells to escape cell cycle regulation and acquire the ability to proliferate indefinitely. Though originating from a single mutation event in one of the originator cells, cancer progresses when the mutant cell lines continue to gain more and more mutations, and finally, become malignant. For example, chronic myelogenous leukemia (CML) develops initially as a non-lethal increase in white blood cells, which progressively...
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Chemical-Induced Skin Carcinogenesis Model Using Dimethylbenz[a]Anthracene and 12-O-Tetradecanoyl Phorbol-13-Acetate DMBA-TPA
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Chemical-Induced Skin Carcinogenesis Model Using Dimethylbenz[a]Anthracene and 12-O-Tetradecanoyl Phorbol-13-Acetate DMBA-TPA

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Revisiting Epithelial Carcinogenesis.

Luis Fernando Méndez-López1

  • 1Centro de Investigación en Nutrición y Salud Pública, Facultad de Salud Pública y Nutrición, Universidad Autonoma de Nuevo Leon, Monterrey 66460, Mexico.

International Journal of Molecular Sciences
|July 9, 2022
PubMed
Summary

Cellular aging and inflammation may drive cancer by enabling epithelial cells to regain plasticity, a process termed dedifferentiation. This hypothesis offers new insights into cancer origins and potential therapeutic strategies.

Keywords:
EMTNAFLDNF-κBTNBCagingepigeneticsinflammationsenescence

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Area of Science:

  • Oncology
  • Cell Biology
  • Aging Research

Background:

  • The origin of cancer is a complex biological enigma.
  • Understanding the early events in carcinogenesis is crucial for effective treatment.

Purpose of the Study:

  • To present a novel hypothesis for the origin of carcinomas.
  • To propose that cellular aging and inflammation drive cancer through dedifferentiation.

Main Methods:

  • Critical review and reinterpretation of molecular, cellular, and histopathological evidence.
  • Postulation of generic mechanisms for carcinoma origin and progression.
  • Discussion of implications for cancer treatment strategies.

Main Results:

  • Hypothesis linking cellular aging, inflammation, and dedifferentiation to cancer initiation.
  • Proposed epigenetic landscape for carcinoma progression and potential therapeutic targets.
  • Integrative mechanistic explanation for tissue degeneration and carcinogenesis in aging.

Conclusions:

  • Cellular aging and inflammation may promote cancer by inducing epithelial cell dedifferentiation.
  • This framework may enhance understanding of degenerative diseases and inspire novel therapies.
  • Epigenetic mechanisms play a role in cancer progression and treatment resistance.