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Updated: Jun 3, 2025

A Simple and Efficient Method for Testing Immunomodulatory Agents for Generation of Tolerogenic Dendritic Cells from Human CD14+ Monocytes
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Dietary Modulation of the Immune System.

Luis Fernando Méndez López1, José Luis González Llerena1, Jesús Alberto Vázquez Rodríguez1

  • 1Universidad Autónoma de Nuevo León, Facultad de Salud Pública y Nutrición, Centro de Investigación en Nutrición y Salud Pública, Monterrey 64460, México.

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Summary

Nutrition significantly impacts immune function, influencing disease prevention and management. Understanding this relationship is key for optimizing health through dietary strategies and targeted supplementation.

Keywords:
chronic diseasesimmunityinfectioninflammationnutrients

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Area of Science:

  • Immunology
  • Nutrition Science
  • Metabolic Diseases

Background:

  • Nutrition profoundly influences the immune system.
  • Dietary strategies are emerging for metabolic-inflammatory diseases.
  • The bidirectional relationship between nutrition and immunocompetence is complex.

Purpose of the Study:

  • To review the bidirectional relationship between nutrition and immunocompetence.
  • To examine the effects of diet on inflammation and disease.
  • To delineate mechanisms of nutrient influence on immune function.

Main Methods:

  • Literature review of immune system components and functions.
  • Analysis of nutritional status, dietary patterns, and bioactives.
  • Examination of nutrient mechanisms and intervention implications.

Main Results:

  • Key nutrients (vitamins A, D, E, C, B; minerals Zn, Fe, Se) modulate immune cells.
  • Polyunsaturated fatty acids, phenolics, and probiotics have immunomodulatory effects.
  • Nutritional interventions can restore immune function but require caution.

Conclusions:

  • Dietary interventions are crucial for managing metabolic-inflammatory diseases.
  • Targeted nutrient supplementation can be effective but carries risks.
  • Integrated dietary counseling ensures safe and effective therapeutic outcomes.