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Shape Memory Polymer-Based Endovascular Devices: Design Criteria and Future Perspective.

Sergio A Pineda-Castillo1,2, Aryn M Stiles1,3, Bradley N Bohnstedt4

  • 1Biomechanics and Biomaterials Design Laboratory (BBDL), The University of Oklahoma, Norman, OK 73019, USA.

Polymers
|July 9, 2022
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Summary

Patient-specific shape memory polymers offer a promising, coil-free solution for intracranial aneurysm embolization, potentially improving long-term complete occlusion rates and reducing recurrence. Further research is needed to overcome current limitations.

Keywords:
3D printingendovascular embolizationintracranial aneurysmspersonalized aneurysm treatmentshape memory polymers

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Area of Science:

  • Biomaterials Science
  • Endovascular Surgery
  • Medical Device Engineering

Background:

  • Current endovascular devices for intracranial aneurysms (ICAs) have suboptimal rates of lasting complete occlusion, leading to recurrence and re-operation.
  • Residual flow within aneurysm sacs is a primary cause of treatment failure and subsequent clinical complications.

Purpose of the Study:

  • To review the limitations of existing endovascular devices for ICA embolization.
  • To explore the potential of patient-specific shape memory polymers (SMPs) as an alternative therapy.
  • To discuss the fabrication, actuation, and application of SMPs for improved ICA treatment.

Main Methods:

  • Review of current literature on endovascular embolization devices for ICAs.
  • Analysis of shape memory polymer properties and fabrication techniques.
  • Evaluation of SMPs' potential for patient-specific aneurysm treatment.

Main Results:

  • Existing devices often fail to achieve complete and durable occlusion of intracranial aneurysms.
  • Shape memory polymers offer tunable properties adaptable to individual aneurysm geometries and hemodynamics.
  • SMPs demonstrate potential as a coil-free endovascular therapy for ICAs.

Conclusions:

  • Patient-specific SMPs represent a promising avenue for enhancing complete occlusion rates in ICA embolization.
  • Further development is required to address existing limitations before widespread clinical application of SMPs.
  • SMPs could offer a more effective, coil-free treatment for intracranial aneurysms.