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Patient-centered trials in oncology: Time for a change
Daniel V Araujo1, Joao A Soler1, Vladmir C Cordeiro de Lima2
1Medical Oncology Department, Hospital de Base, São José do Rio Preto, Brazil.
Med (New York, N.Y.)
|July 9, 2022
Summary
Patient-centered clinical trials are crucial for efficient oncology progress. This commentary examines the decline of patient-centric approaches in modern trials and offers solutions to recenter patients.
Area of Science:
- Oncology
- Clinical Trial Design
- Patient Advocacy
Background:
- Patient-centered trials are essential for effective oncology research and development.
- Contemporary clinical trials are increasingly moving away from patient-centric methodologies.
- This shift risks hindering efficient advancement in cancer care.
Purpose of the Study:
- To identify and describe common non-patient-centric practices in current oncology trials.
- To discuss the negative implications of these non-patient-centric approaches.
- To propose actionable solutions for re-establishing patient centrality in clinical trials.
Main Methods:
- Commentary and critical analysis of current clinical trial practices.
- Review of literature and expert opinion on patient-centered care in oncology.
- Synthesis of common deviations from patient-centric principles.
Main Results:
- Several non-patient-centric practices are prevalent in contemporary oncology trials.
- These practices can lead to decreased patient engagement, suboptimal data, and slower therapeutic progress.
- Specific examples of non-patient-centric designs and operational aspects are highlighted.
Conclusions:
- Reintegrating patient perspectives and priorities is vital for the future of oncology research.
- Implementing proposed solutions can help restore patient centrality in clinical trial design and execution.
- A renewed focus on patient-centeredness will enhance the efficiency and relevance of oncology trials.
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