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Biomarkers in Heart Failure with Preserved Ejection Fraction
Antoni Bayes-Genis1,2,3, Germán Cediel1,3, Mar Domingo1,3
1Heart Institute, University Hospital Germans Trias i Pujol Badalona, Spain.
Cardiac Failure Review
|July 11, 2022
Summary
Diagnosing heart failure with preserved ejection fraction (HFpEF) is difficult. Biomarkers for myocardial stretch, injury, and non-cardiac factors aid diagnosis and phenotyping.
Area of Science:
- Cardiology
- Biomarker Discovery
- Translational Medicine
Background:
- Heart failure with preserved ejection fraction (HFpEF) is a complex, heterogeneous condition with challenging diagnosis.
- Current diagnostic methods like imaging and physical exams lack sensitivity for HFpEF.
- Understanding HFpEF requires exploring diverse etiological and pathophysiological mechanisms.
Purpose of the Study:
- To review and summarize current and emerging biomarkers for HFpEF diagnosis and phenotyping.
- To highlight the role of cardiac and non-cardiac biomarkers in understanding HFpEF.
- To discuss the potential of novel -omics technologies in advancing HFpEF research.
Main Methods:
- Comprehensive literature review of HFpEF biomarkers.
- Analysis of established biomarkers including natriuretic peptides and cardiac troponins.
- Exploration of novel biomarkers from inflammation, fibrosis, senescence, vascular dysfunction, metabolic profiles, and microRNAs.
Main Results:
- Natriuretic peptides and cardiac troponins are well-supported biomarkers related to myocardial stretch and injury.
- Biomarkers for inflammation, fibrosis, senescence, vascular dysfunction, iron deficiency, and obesity offer insights into HFpEF's complexity.
- Emerging -omics technologies reveal potential novel biomarkers like plasma metabolites and microRNAs.
Conclusions:
- A cardiac-centered approach using natriuretic peptides is currently practical for HFpEF diagnosis.
- A holistic biomarker strategy encompassing non-cardiac factors can enhance HFpEF understanding and phenotyping.
- Biomarker-guided phenotyping may refine patient selection for clinical trials in HFpEF.
Keywords:
Heart failure with preserved ejection fractionfibrosisinsulin-like growth factor-binding protein-7interleukin-1 receptorlike 1natriuretic peptidestroponinMore Related Videos
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