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Related Concept Videos

Larynx01:21

Larynx

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The human larynx, often referred to as the voice box, is an intricate organ located in the neck. It serves as a pathway for air to enter the lungs during respiration and is an essential component of voice production.
Anatomy of the Larynx
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Tuberculosis, or TB, is a bacterial infectious disease caused by Mycobacterium tuberculosis. While its primary impact is on the lungs, leading to pulmonary tuberculosis, it can also affect various other organs, a condition referred to as extrapulmonary tuberculosis.
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In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA...
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Updated: Sep 5, 2025

Detection of Invasive Pulmonary Aspergillosis in Haematological Malignancy Patients by using Lateral-flow Technology
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Laryngeal histoplasmosis: masquerading malignancy.

Devendra Kumar Gupta1, Deepika Tanwar2, Bhaumik Patel1

  • 1ENT-HNS, Army Hospital Research and Referral, New Delhi, Delhi, India.

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|July 11, 2022
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Summary
This summary is machine-generated.

Laryngeal histoplasmosis, a rare cause of laryngitis, can affect even healthy individuals. This case highlights its diagnosis and successful treatment in an immunocompetent patient.

Keywords:
Ear, nose and throatEar, nose and throat/otolaryngologyHead and neck cancerInfections

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Area of Science:

  • Infectious Diseases
  • Otolaryngology
  • Mycology

Background:

  • Laryngeal histoplasmosis is an uncommon infection of the voice box, often associated with weakened immune systems.
  • It can, however, manifest in individuals with normal immune function, presenting diagnostic challenges.

Observation:

  • A man in his 60s, a chronic smoker, experienced progressive hoarseness over three months.
  • A biopsy of a glottic growth was performed due to persistent symptoms.

Findings:

  • Histopathological examination of the laryngeal tissue confirmed the presence of Histoplasma capsulatum, diagnosing laryngeal histoplasmosis.
  • The patient was immunocompetent, underscoring the possibility of this infection in non-immunosuppressed individuals.

Implications:

  • This case emphasizes the importance of considering rare infections like laryngeal histoplasmosis in the differential diagnosis of hoarseness.
  • Prompt diagnosis through histopathology and appropriate antifungal treatment, including liposomal amphotericin B and itraconazole, led to complete symptom resolution.