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Intravital Imaging of Intraepithelial Lymphocytes in Murine Small Intestine

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Primary Intestinal Lymphoma in Rabbits.

Jessica Magnotti¹, Daniel Bland², Michael M Garner³

¹Stahl Exotic Animal Veterinary Services, Fairfax, Virginia, USA.

Journal of Comparative Pathology

|July 11, 2022

Summary

Primary intestinal lymphoma is rare in rabbits. This case series details four rabbit cases, identifying B-cell lineage and classifying them as diffuse large B-cell lymphoma or lymphoblastic lymphoma.

Keywords:

B-cell lymphoma neoplasia primary intestinal lymphoma rabbits

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Long-Term Catheterization of the Intestinal Lymph Trunk and Collection of Lymph in Neonatal Pigs

Long-Term Catheterization of the Intestinal Lymph Trunk and Collection of Lymph in Neonatal Pigs

Published on: March 5, 2016

Area of Science:

Veterinary Pathology
Oncology
Rabbit Medicine

Background:

Intestinal neoplasms are uncommon in rabbits.
Primary intestinal lymphoma is a rare condition in this species.
This study provides the first detailed description of primary intestinal lymphoma in rabbits.

Purpose of the Study:

To describe the clinicopathologic features of primary intestinal lymphoma in rabbits.
To characterize the neoplastic lymphocytes and classify the lymphomas based on established criteria.

Main Methods:

Retrospective review of four rabbit cases diagnosed with primary intestinal lymphoma.
Histopathological examination and immunohistochemical analysis (CD79a, CD3) of neoplastic lymphocytes.
Classification according to the Revised European-American Classification of Lymphoid Neoplasms/World Health Organization criteria.

Main Results:

Cases involved rabbits aged 5-9.5 years (average 7.8 years).
Neoplastic cells were large (8 µm) in three cases and intermediate (5 µm) in one case.
Immunohistochemistry confirmed B-cell lineage (CD79a positive, CD3 negative).
Three cases were classified as diffuse large B-cell lymphoma; one as lymphoblastic lymphoma.

Conclusions:

Primary intestinal lymphoma in rabbits is a B-cell neoplasm.
The condition can be classified using human lymphoma diagnostic criteria.
This research contributes to understanding rare rabbit neoplasms.