Related Experiment Video

Updated: Sep 5, 2025

Closure of a Patent Foramen Ovale PFO: An Intervention Sequence
10:52

Closure of a Patent Foramen Ovale PFO: An Intervention Sequence

Published on: December 23, 2022

3.6K

Migraine in Patients Undergoing PFO Closure: Characterization of a Platelet-Associated Pathophysiological Mechanism:

Daniela Trabattoni1, Marta Brambilla1, Paola Canzano1

  • 1Centro Cardiologico Monzino IRCCS, Milan, Italy.

JACC. Basic to Translational Science
|July 12, 2022
PubMed

Insights

Migraine patients with a patent foramen ovale (PFO) show increased platelet activation and a prothrombotic state. PFO closure led to migraine remission and normalization of platelet function.

Area of Science:

  • Cardiovascular Medicine
  • Neurology
  • Hematology

Background:

  • The association between migraine and patent foramen ovale (PFO) is established.
  • Migraineurs with PFO may exhibit altered platelet behavior and oxidative stress.

Purpose of the Study:

  • To investigate platelet activation, prothrombotic phenotype, and oxidative stress in migraineurs with PFO.
  • To assess changes before and after PFO closure in patients on aspirin therapy.

Main Methods:

  • Studied platelet activation markers, tissue factor expression, and thrombin generation potential.
  • Assessed oxidative stress status in migraineurs with PFO and aspirin-treated healthy controls.
  • Evaluated changes 6 months after PFO closure.

Main Results:

  • Before PFO closure, migraineurs with PFO showed increased prothrombotic phenotype and altered oxidative stress compared to controls.
  • Platelet phenotype was more influenced by P2Y12-blockade than aspirin.
  • PFO closure resulted in complete migraine remission and normalization of the prothrombotic phenotype.

Conclusions:

  • Patent foramen ovale closure is associated with reduced platelet prothrombotic activity and oxidative stress in migraine patients.
  • PFO closure can lead to significant migraine symptom improvement.
  • Targeting platelet activation pathways may be beneficial for migraineurs with PFO.
Keywords:
GSH, reduced glutathioneGSSG, oxidized glutathioneHS, healthy subject(s)MHA, migraine headache with auraMV, microvesiclesNAC, N-acetylcysteinePFO, patent foramen ovalePS, phosphatidylserineROS, reactive oxygen speciesTF, tissue factorWB, whole bloodcTTE, contrast transthoracic echocardiographymigraine with auraoxidative stresspatent foramen ovaleplateletstissue factor

More Related Videos

Echocardiographic Evaluation of Atrial Communications before Transcatheter Closure07:41

Echocardiographic Evaluation of Atrial Communications before Transcatheter Closure

Published on: February 8, 2022

3.8K
3D-Neuronavigation In Vivo Through a Patient's Brain During a Spontaneous Migraine Headache10:39

3D-Neuronavigation In Vivo Through a Patient's Brain During a Spontaneous Migraine Headache

Published on: June 2, 2014

18.3K

Related Concept Videos

Formation of the Platelet Plug01:22

Formation of the Platelet Plug

The platelet phase, the second stage of hemostasis, commences around 15-20 seconds after an injury. It follows and overlaps with the vascular phase, during which blood vessels constrict to minimize blood loss.
As the injured blood vessel contracts, endothelial cells undergo contraction, revealing collagen fibers in the basement membrane and underlying connective tissue. Furthermore, the plasma membrane of endothelial cells becomes adhesive, preparing the site for platelet adhesion. Platelets...
7.0K
Structure and Function of Platelets01:18

Structure and Function of Platelets

The cell fragments known as platelets are disc-shaped, with an average diameter of about 3 μm and a thickness of roughly 1 μm. They play a crucial role in the body's vascular clotting system, which also involves plasma proteins, blood cells, and blood vessel tissues.
Platelets are continually replenished, circulating in the bloodstream for 9-12 days before being removed by phagocytes, primarily in the spleen. A microliter of circulating blood contains between 150,000 and 450,000...
1.5K
Antiplatelet Drugs: Prostaglandin Synthesis, P2Y12 and Glycoprotein IIb/IIIa Inhibitors01:20

Antiplatelet Drugs: Prostaglandin Synthesis, P2Y12 and Glycoprotein IIb/IIIa Inhibitors

Antiplatelet drugs emerge as frontline defenders against the insidious threat of thromboembolic diseases, where abnormal clots obstruct vital blood vessels. These drugs stand as bulwarks, inhibiting platelet aggregation and clot formation, thereby mitigating the risk of life-threatening conditions like myocardial infarction, coronary artery disease, and thrombotic strokes.
Prostaglandin synthesis inhibitors, exemplified by the widely known aspirin, wield their power by irreversibly acetylating...
630
Mitral Valve Prolapse I: Introduction01:27

Mitral Valve Prolapse I: Introduction

IntroductionThe mitral valve, one of the heart's four valves, regulates blood flow. These valves have flaps that open and close to direct blood properly through the heart and body. During each heartbeat, the flaps open for blood to pass through and seal shut to prevent backflow. Specifically, the mitral valve opens to allow blood flow from the heart's upper left chamber to the lower left chamber. It then closes securely as the lower left chamber contracts to pump blood to the body, preventing...
37
Clot Retraction and Fibrinolysis01:16

Clot Retraction and Fibrinolysis

After a fibrin clot is formed, the next step is clot retraction, a vital process facilitated by platelet contractile proteins, such as actin and myosin. These proteins pull the fibrin strands closer together and condense the clot. This action reduces the size of the clot, creating a smaller, denser structure that effectively seals off the damaged vessel. Clot retraction consolidates the clot and helps with wound healing by bringing the edges of the damaged blood vessel closer together.
6.8K
Introduction to Hemostasis01:05

Introduction to Hemostasis

Hemostasis is a complex physiological process that prevents excessive bleeding when a blood vessel is injured. It's crucial for maintaining the integrity of the circulatory system, as it ensures that our blood remains fluid while still within the vascular network and yet clots to prevent blood loss upon vessel injury.
The three phases of hemostasis involve many clotting factors present in plasma and several substances released by platelets and injured tissue cells. It is a fast, localized,...
8.8K